Latest Articles

Latest Articles have been peer-reviewed and accepted, which are not yet assigned to volumes/issues, but are citable by Digital Object Identifier (DOI).
Ramulus Mori alkaloids (SZ-A) sensitize triple-negative breast cancer to cisplatin via PLA2G2A-mediated ceramide metabolism
Chen Chao, Wan Mengqi, Zhu Zhixu, Xie Zhaoyu, Zhang Yu, Xu Tao, Meng Han, Wu Miaomiao, Gui Liangfeng, Lv Hongbo, Wang Guodong, Han Jun, Che Hui
Abstract FullText HTML PDF
Self-assembled nanoaggregates in Wuzhuyu decoction: formation, absorption, transport, and alleviation of chronic migraine
Wang Qi, Guo Xiaomeng, Li Meijing, Nan Nan, Zhang Zekuan, Song Zhimin, Zhou Ziwei, Zhang Nan, He Rui, Li Jing, Zhao Hui, Liu Renhui, Qu Miao, Gong Muxin
Abstract FullText HTML PDF
Natural cyclopeptide RA-V induces ER stress and promotes HRD1-mediated c-Myc degradation to inhibit pancreatic cancer stemness
Jiang Zhuangzhuang, Wu Yingwei, Cao Feng, Wang Jianghao, Ye Shuqing, Sui Yihang, Tan Ninghua
Abstract FullText HTML PDF
Modulating the gut microbiota: a multi-target mechanism of traditional Chinese medicine for type 2 diabetes management
Ding Zhiping, Li Qunfang, Li Zi, Li Xiuyang
Abstract FullText HTML PDF
Organ-on-a-Chip in Natural Product Research: Advancing Translational ADME, Efficacy and Safety Assessment
Hao Lijun, Ge Ye, Wang Tingting, Wang Guangji, Zhang Jingwei
Abstract FullText HTML PDF
Comorbid depression exacerbates Gelsemium elegans toxicity via disruption of the Clostridium-LCA-PXR-CYP3A11 metabolic axis
Zhang Fugui, Hu Wanyu, Zhao Xiaojie, Fu Bingxuan, Lin Yating, Xie Cong, Yang Ruopeng, Fu Yufang, Tan Weiling, Ye Ling
Abstract FullText HTML PDF
Identification and characterization of a promiscuous pentacyclic triterpenoid O-glycosyltransferase from Phytolacca americana
Zhang Yi, Wang Jinxin, Zhu Yiqing, Shen Yunheng, Dong Hongyuan, Yu Haiyang, An Zirui, Zhang Weidong, Zhang Yu, Hu Zhimin
Abstract FullText HTML PDF
Discovery and synthesis of 3-amino glycyrrhizin derivative containing guanidyl with anti-colorectal cancer activity
Liu Jianrong, Zhang Jingke, Wu Tianbo, Jin Tingting, Zhao Quanyi, He Dian
Abstract FullText HTML PDF
Genistein inhibits oxidative stress and alleviate vascular remodeling in hypertension through the GSK3β/Fyn/Nrf2 pathway
Zhang Xiaotong, Xie Yixuan, Wu Zhijing, Xi Dongmei, Tang Na, Li Xinzhi, Ma Ketao
Abstract FullText HTML PDF
Multimethod-guided discovery of novel α-pyrone dimers with cardiomyocyte-protective activity against cold ischemia injury from the coral-derived Talaromyces sp. TJ403-AL05
Zeng Hanxiao, Wang Yaxing, Huang Chenmeng, Jiang Rui, Zhang Yongfei, Chai Zixue, Chi Jiangyang, Zhang Yonghui, Hu Zhengxi
Abstract FullText HTML PDF
Clavukellines A–N: Dolabellane Diterpenes from the Soft Coral Clavularia koellikeri
Lu Zhong-Yu, Zhu Xiao, Zhou Xin, Li Xiao-Bin, Han Xiao, Li Guo-Qiang
Abstract FullText HTML PDF
Aspergillines E−L with TDPs Inhibitory and Combined Anti-tumor Activities from Marine Fungus Aspergillus sp. EGF 15-0-3 as Environmental-Induced Products
Wei Xia, Guo Li-Shuang, Duan Xue-Wei, Zhang Ze-Kun, An Lin-Kun, Su Jun-Cheng, Zhang Cui-Xian
Abstract FullText HTML PDF
Nuciferine ameliorates cognitive impairment and insulin resistance in T2DM by targeting the insulin receptor and activating PI3K/AKT signaling
Zheng Miao, Wang Can, Liu Jiayi, Xia Yi, Zhang Xinyue, Gu Lili
DOI: 10.1016/S1875-5364(25)60990-3
Abstract FullText HTML PDF
Function-oriented synthesis of marine phidianidine derivatives as potent anti-MRSA agents
Wu Qiong, Yan Bing-Yuan, Qu Chen, Ma Chao, Li Xu-Wen
Abstract FullText HTML PDF
The therapeutic potential of saponins for neurological diseases via the gut-brain axis
Wang Xuejing, Li Shiyin, Zhong Guangcheng, Zhang Ting, Chen Qini, Jing Shangwen, Liu Shan, Liu Junhui, Wang Qi
Abstract FullText HTML PDF
Naringenin Ameliorates Iron Overload-Associated Osteoporosis via Tfeb/p62/Nrf2-Mediated Antioxidation
Pan Zhaofeng, Li Miao, Chen Baihao, Lu Jiaxin, Wang Fanchen, Meng Chenhui, Wang Xintian, Shao Min, He Qi, Wang Haibin
Abstract FullText HTML PDF
Highly oxygenated cembrane diterpenoids from the South China Sea soft coral Sinularia pedunculata and their anti-HBV activities
Sun Ruonan, Huang Chao, Gao Zhen, Yao Ligong, Guo Yuewei, Chen Jieliang, Li Xuwen
DOI: 10.1016/S1875-5364(25)60965-4
Abstract FullText HTML PDF
Discovery of dimeric costunolide-triazole conjugates as antihepatoma agents via integrating dimerization and molecular hybridization
Li Tianze, Jiang Chenxi, Li Qihao, Hu Min-min, Li Yabo, Yang Yao, Ma Yunbao, Wang Yongcui, Chen Jijun
DOI: 10.1016/S1875-5364(26)61098-9
Abstract FullText HTML PDF
Discovery of bioactive constituents from Inula britannica and their anti-pneumonia effects
Wang Na, Hui Siwen, Sun Jianbo, Xu Xinrong, Zhang Huilin, Chang Jing, Zhu Qimeng, Jia Yaxue, Shu Xiaohong, Zhang Juan, Sun Chengpeng
Abstract FullText HTML PDF
Quzhou Fructus Aurantii extract alleviates metabolic dysfunction-associated steatohepatitis by activating the PPARα signaling pathway
Wu Lianhao, Zhu Wenwen, Zhang Shuohan, Chen Ranran, Wang Junyi, Shui Yiyang, Sun Yi, Zhang Sheng, Tao He, Wu Yueguo, Yuan Yu, You Zhenqiang
DOI: 10.1016/S1875-5364(26)61070-9
Abstract FullText HTML PDF
Pinoresinol diglucoside from Eucommia ulmoides attenuates diabetic cardiomyopathy through suppressing the store-operated calcium entry and downregulating the STIM1/Orai1/NFAT3 signaling pathway  
Feng Yujie, Mao Yanan, Li Junshuai, Sun Zhipeng, Wang Yingchao, Wang Xinru, Wang Feng, Liu Tiantian, Zhang Lane
DOI: 10.1016/S1875-5364(26)61114-4
Abstract FullText HTML PDF
Dual targeting of cutaneous inflammation and vasculopathy via STING-NF-κB blockade underlies the anti-psoriatic efficacy of Yinxie Granules
Zou Jueyao, Hu Tongyao, Zhang Zhengyu, He Yong, Wang Yuxin, Zhou Yixiao, Zhu Ziyan, Yu Suyun, Zou Wei, Wei Zhonghong, Zhao Yang, Pan Yanhong, Chen Wenxing, Lu Yin
DOI: 10.1016/S1875-5364(26)61112-0
Abstract FullText HTML PDF
Anti-pathogenic effects of Artemisia argyi and its applications: the past, present, and future
Chen Le, Deng Xinran, Xiao Xiang, Yang Jinglin, Hou Xiaoying, Liu Dahui, Du Hongzhi
DOI: 10.1016/S1875-5364(26)61113-2
Abstract FullText HTML PDF
Battle of the wall for aromatic “orifice-opening” agents: defending and breaching the blood-brain barrier
Yang Xiaoman, Zhang Jing, Yu Hao, Zhao Yulei, Hou Guanqun, Wang Shijun, Han Bingbing
DOI: 10.1016/S1875-5364(26)61099-0
Abstract FullText HTML PDF
“Marine Rule”: Discovery of marine natural small molecule drug leads in China in the past decade
Chen Xinqi, Zhang Xi, Chen Chunmei, She Jianglian, Liu Yonghong, Zhang Cuixian, Cai Jian, Tang Lan, Zhou Xuefeng
Abstract FullText HTML PDF
Hydrolyzed Ginsenosides of Panax notoginseng Flowers Attenuate Alcoholic Liver Disease by Inhibiting Oxidative Stress and Lipid Accumulation
Shen Hong, Ma Li-Juan, Wang Kang-Hui, Zhou Jun-Yi, Liu Jia-Yue, Wan Jian-Bo
DOI: 10.1016/S1875-5364(26)61118-1
Abstract FullText HTML PDF
Targeting Vascular Smooth Muscle Cells with Natural Compounds to Combat Atherosclerosis
Qin Xiangyue, Zhou Zi han, Zheng Zuguo, Wen Xiaodong, Yang Hua
DOI: 10.1016/S1875-5364(26)61117-X
Abstract FullText HTML PDF
Quercetin Reverses the Breast Cancer-promoting Effects of Depression by Targeting PPARγ
Wu Yingchao, Liang Yuqi, Chen Liushan, Chen Jieting, Huang Junfeng, Yang Congwen, Zuo Qian, Chen Qianjun
Abstract FullText HTML PDF
Traditional Chinese medicine-based drug delivery systems for anti-tumor therapies
Yang Lin, Wang Yani, Ye Xietao, Liu Qiaoming, Qu Ding, Chen Yan
DOI: 10.1016/S1875-5364(25)60860-0
Abstract FullText HTML PDF
Research progress of small-molecule natural medicines for the treatment of ischemic stroke
Liu Kui, Wang Ling, Pang Tao
DOI: 10.1016/S1875-5364(24)60712-0
Abstract FullText HTML PDF