中国天然药物

优先发表栏目展示本刊经同行评议确定正式录用的文章，这些文章目前处在编校过程，尚未确定卷期及页码，但可以根据DOI进行引用。

Naturally derived oncolytic peptides: From discovery to clinical translation

Zhang Jiyuan, Chen Yi, Lu Shengxin, Zhang Xiaokun, Yang Guanrunze, Zhang Zhidan, Wu Ye, Zhang Xuemei, Zhang Weidong

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Advances in extraction, purification, and pharmacological mechanisms of calycosin: a comprehensive review

Liang Keke, Chen Chao, Xu Liang, Ma Shuhe, Ta Yanlin, Wang Renjie, Xiao Chenrong, Zhang Xianxie, Hao Feiran, Gao Yue, Li Maoxing

DOI: 10.1016/S1875-5364(25)60988-5

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Organ-on-a-Chip in Natural Product Research: Advancing Translational ADME, Efficacy and Safety Assessment

Hao Lijun, Ge Ye, Wang Tingting, Wang Guangji, Zhang Jingwei

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Comorbid depression exacerbates Gelsemium elegans toxicity via disruption of the Clostridium-LCA-PXR-CYP3A11 metabolic axis

Zhang Fugui, Hu Wanyu, Zhao Xiaojie, Fu Bingxuan, Lin Yating, Xie Cong, Yang Ruopeng, Fu Yufang, Tan Weiling, Ye Ling

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Morin enhances the renoprotective effects of Empagliflozin in diabetic kidney disease via targeting ATF6-DAPK1 signaling

Lei Yi, Gao Chenlin, Zhao Xin, Huang Wei, Jiang Chunxia, Wu Qi, Law Betty Yuen Kwan, Xu Yong

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Echinacoside targets HSC70 to promote osteoblast differentiation via Wnt/β-catenin signaling activation and mitochondrial regulation

Han Dong, Chen Shihao, Wu Xiaojuan, Jiang Xiaoli, Li Ping, Xu Weilong, Li Fei

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Identification and characterization of a promiscuous pentacyclic triterpenoid O-glycosyltransferase from Phytolacca americana

Zhang Yi, Wang Jinxin, Zhu Yiqing, Shen Yunheng, Dong Hongyuan, Yu Haiyang, An Zirui, Zhang Weidong, Zhang Yu, Hu Zhimin

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Discovery and synthesis of 3-amino glycyrrhizin derivative containing guanidyl with anti-colorectal cancer activity

Liu Jianrong, Zhang Jingke, Wu Tianbo, Jin Tingting, Zhao Quanyi, He Dian

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Genistein inhibits oxidative stress and alleviate vascular remodeling in hypertension through the GSK3β/Fyn/Nrf2 pathway

Zhang Xiaotong, Xie Yixuan, Wu Zhijing, Xi Dongmei, Tang Na, Li Xinzhi, Ma Ketao

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Multimethod-guided discovery of novel α-pyrone dimers with cardiomyocyte-protective activity against cold ischemia injury from the coral-derived Talaromyces sp. TJ403-AL05

Zeng Hanxiao, Wang Yaxing, Huang Chenmeng, Jiang Rui, Zhang Yongfei, Chai Zixue, Chi Jiangyang, Zhang Yonghui, Hu Zhengxi

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Apocynum venetum leaf extract ameliorates postmenopausal osteoporosis by inhibiting RANKL-induced osteoclastogenesis

Chen Yongyan, Gao Shuo, Xu Yunqing, Chen Jiebo, Liu Congwei, Wang Zhenwu, Zeng Zhiping, Lin Ting, Zhou Hu

DOI: 10.1016/S1875-5364(25)60979-4

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Clavukellines A–N: Dolabellane Diterpenes from the Soft Coral Clavularia koellikeri

Lu Zhong-Yu, Zhu Xiao, Zhou Xin, Li Xiao-Bin, Han Xiao, Li Guo-Qiang

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Aspergillines E−L with TDPs Inhibitory and Combined Anti-tumor Activities from Marine Fungus Aspergillus sp. EGF 15-0-3 as Environmental-Induced Products

Wei Xia, Guo Li-Shuang, Duan Xue-Wei, Zhang Ze-Kun, An Lin-Kun, Su Jun-Cheng, Zhang Cui-Xian

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Micranthin B alleviates metabolic dysfunction-associated steatohepatitis by targeting G3BP1 to improve stress granule-mediated endoplasmic reticulum stress

Cheng Yang, Wang Jingyi, He Mengmeng, Wu Enyi, Ye Shengtao, Zheng Ying, Zhang Yanqiu, Kong Lingyi, Zhang Hao

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Resveratrol's hepatic symphony: conducting a multi-stage intervention in liver cancer’s progression

Guo Cui, Cao Fang, Zhou Ling, Guo Guijun, Zheng Shaoyuan, Xia Ruixue, Zou Qinghua

DOI: 10.1016/S1875-5364(25)60951-4

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Nuciferine ameliorates cognitive impairment and insulin resistance in T2DM by targeting the insulin receptor and activating PI3K/AKT signaling

Zheng Miao, Wang Can, Liu Jiayi, Xia Yi, Zhang Xinyue, Gu Lili

DOI: 10.1016/S1875-5364(25)60990-3

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Function-oriented synthesis of marine phidianidine derivatives as potent anti-MRSA agents

Wu Qiong, Yan Bing-Yuan, Qu Chen, Ma Chao, Li Xu-Wen

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The therapeutic potential of saponins for neurological diseases via the gut-brain axis

Wang Xuejing, Li Shiyin, Zhong Guangcheng, Zhang Ting, Chen Qini, Jing Shangwen, Liu Shan, Liu Junhui, Wang Qi

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Naringenin Ameliorates Iron Overload-Associated Osteoporosis via Tfeb/p62/Nrf2-Mediated Antioxidation

Pan Zhaofeng, Li Miao, Chen Baihao, Lu Jiaxin, Wang Fanchen, Meng Chenhui, Wang Xintian, Shao Min, He Qi, Wang Haibin

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Highly oxygenated cembrane diterpenoids from the South China Sea soft coral Sinularia pedunculata and their anti-HBV activities

Sun Ruonan, Huang Chao, Gao Zhen, Yao Ligong, Guo Yuewei, Chen Jieliang, Li Xuwen

DOI: 10.1016/S1875-5364(25)60965-4

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Discovery of dimeric costunolide-triazole conjugates as antihepatoma agents via integrating dimerization and molecular hybridization

Li Tianze, Jiang Chenxi, Li Qihao, Hu Min-min, Li Yabo, Yang Yao, Ma Yunbao, Wang Yongcui, Chen Jijun

DOI: 10.1016/S1875-5364(26)61098-9

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Discovery of bioactive constituents from Inula britannica and their anti-pneumonia effects

Wang Na, Hui Siwen, Sun Jianbo, Xu Xinrong, Zhang Huilin, Chang Jing, Zhu Qimeng, Jia Yaxue, Shu Xiaohong, Zhang Juan, Sun Chengpeng

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Quzhou Fructus Aurantii extract alleviates metabolic dysfunction-associated steatohepatitis by activating the PPARα signaling pathway

Wu Lianhao, Zhu Wenwen, Zhang Shuohan, Chen Ranran, Wang Junyi, Shui Yiyang, Sun Yi, Zhang Sheng, Tao He, Wu Yueguo, Yuan Yu, You Zhenqiang

DOI: 10.1016/S1875-5364(26)61070-9

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Pinoresinol diglucoside from Eucommia ulmoides attenuates diabetic cardiomyopathy through suppressing the store-operated calcium entry and downregulating the STIM1/Orai1/NFAT3 signaling pathway  

Feng Yujie, Mao Yanan, Li Junshuai, Sun Zhipeng, Wang Yingchao, Wang Xinru, Wang Feng, Liu Tiantian, Zhang Lane

DOI: 10.1016/S1875-5364(26)61114-4

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Dual targeting of cutaneous inflammation and vasculopathy via STING-NF-κB blockade underlies the anti-psoriatic efficacy of Yinxie Granules

Zou Jueyao, Hu Tongyao, Zhang Zhengyu, He Yong, Wang Yuxin, Zhou Yixiao, Zhu Ziyan, Yu Suyun, Zou Wei, Wei Zhonghong, Zhao Yang, Pan Yanhong, Chen Wenxing, Lu Yin

DOI: 10.1016/S1875-5364(26)61112-0

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Anti-pathogenic effects of Artemisia argyi and its applications: the past, present, and future

Chen Le, Deng Xinran, Xiao Xiang, Yang Jinglin, Hou Xiaoying, Liu Dahui, Du Hongzhi

DOI: 10.1016/S1875-5364(26)61113-2

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Battle of the wall for aromatic “orifice-opening” agents: defending and breaching the blood-brain barrier

Yang Xiaoman, Zhang Jing, Yu Hao, Zhao Yulei, Hou Guanqun, Wang Shijun, Han Bingbing

DOI: 10.1016/S1875-5364(26)61099-0

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“Marine Rule”: Discovery of marine natural small molecule drug leads in China in the past decade

Chen Xinqi, Zhang Xi, Chen Chunmei, She Jianglian, Liu Yonghong, Zhang Cuixian, Cai Jian, Tang Lan, Zhou Xuefeng

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Nature’s nano-shield: plant-based essential oil nano-emulsions as potent defenders against microbial invaders and skin wounds

Do Khai Ly, Mushtaq Asim, Iqbal Muhammad Zubair, Ahsan Taswar, Liu Xiangdong, Su Miao

DOI: 10.1016/S1875-5364(25)60908-3

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Hydrolyzed Ginsenosides of Panax notoginseng Flowers Attenuate Alcoholic Liver Disease by Inhibiting Oxidative Stress and Lipid Accumulation

Shen Hong, Ma Li-Juan, Wang Kang-Hui, Zhou Jun-Yi, Liu Jia-Yue, Wan Jian-Bo

DOI: 10.1016/S1875-5364(26)61118-1

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Targeting Vascular Smooth Muscle Cells with Natural Compounds to Combat Atherosclerosis

Qin Xiangyue, Zhou Zi han, Zheng Zuguo, Wen Xiaodong, Yang Hua

DOI: 10.1016/S1875-5364(26)61117-X

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Huatuo Zaizao Pills improve myocardial ischemia by inhibiting extracellular calcium influx

Nannan Wang, Shifeng Cao, Yu Zhao, Yanrong Li, Jiewen Zhou, Shuyu Liu, Huan Chen, Na An, Linhe Liu, Yixiu Zhao, Hongxia Zhao, Na Ning, Zhang Yan, Yang Baofeng

DOI: 10.1016/S1875-5364(26)61096-5

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Quercetin Reverses the Breast Cancer-promoting Effects of Depression by Targeting PPARγ

Wu Yingchao, Liang Yuqi, Chen Liushan, Chen Jieting, Huang Junfeng, Yang Congwen, Zuo Qian, Chen Qianjun

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Traditional Chinese medicine-based drug delivery systems for anti-tumor therapies

Yang Lin, Wang Yani, Ye Xietao, Liu Qiaoming, Qu Ding, Chen Yan

DOI: 10.1016/S1875-5364(25)60860-0

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Research progress of small-molecule natural medicines for the treatment of ischemic stroke

Liu Kui, Wang Ling, Pang Tao

DOI: 10.1016/S1875-5364(24)60712-0

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栏目

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Recent applications of Traditional Chinese Medicine in cosmetology: a Review

Zheng Hanzi, Wu Sicheng, Wang Shuhan, Winkeljann Benjamin, Liao Liqiong, Song Jian

2026, 24(5): 513-525. DOI: 10.1016/S1875-5364(26)61176-4

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Rhubarb in renal fibrosis: from traditional ethnopharmacology to mechanistic therapeutic development

Liu Minna, Li Xiaolin, Zhang Lu, Lu Lu, Li Jinhu, Liu Tianlong, Chen Keming

2026, 24(5): 526-542. DOI: 10.1016/S1875-5364(26)61177-6

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Marine-derived products as pharmaceutical treasure troves: a focus on recent research techniques and potential bioactive activities of marine peptides

Cheng Xiangyu, Tang Ziqi, Li Zhongqi, Hu Shuaijie, Qin Kehan, Zhao Yindi, Hao Baoming, Hu Qinghua

2026, 24(5): 543-558. DOI: 10.1016/S1875-5364(26)61178-8

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Network pharmacology and AI: illuminating the path to precision herbal medicine in Ganoderma spp.

Sharma Aman, Khanal Sonali, Suvedi Divyesh, Yadav Neelesh, Verma Rachna, Kumar Dinesh, Tapwal Ashwani, Peter Lukas, Kumar Vinod

2026, 24(5): 559-573. DOI: 10.1016/S1875-5364(26)61083-7

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Yangxinshi Tablet protects against post-myocardial infarction heart failure with reduced ejection fraction by improving energy metabolism through inhibition of FOXO1/PDK4 signaling

Guo Jingwen, Miao Rong, Fan Qingying, Li Yilin, Tian Yuhua, Sun Aomei, Zhang Qingrui, Lv Zhenguo, Qi Guangwei, Francis Opoku Bonsu, Liu Rui, Chen Ting, Liu Qin, Li Ruiqiao, He Jun, Sun Yan, Leng Ling, Jiang Miaomiao, Wang Qilong

2026, 24(5): 574-591. DOI: 10.1016/S1875-5364(26)61119-3

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Nobiletin inhibits non-small cell lung cancer through TRKC and exhibits a synergistic effect with the HDAC inhibitor

Wang Yuanru, Fan Fang, Yang Xue, Li Yuqian, Li Luyao, Lei Qiqi, Xiang Liuyan, Zhang Xiaoqian, Cao Yajun, Li Xuejun

2026, 24(5): 592-603. DOI: 10.1016/S1875-5364(26)61084-9

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Potential therapeutic benefits of Murraya exotica L. extract on type II collagen-induced arthritis

Wu Guoping, Fan Yuxin, Yao Yawen, Ma Qiushuo, Chen Qiling, Chen Junming, Xie Wenbo, Yu Hua

2026, 24(5): 604-618. DOI: 10.1016/S1875-5364(26)61179-X

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Silibinin meglumine ameliorates hepatic encephalopathy via inhibiting UCP2-mediated oxidative stress and mitochondrial dysfunction

Li Yue, Chen Hong, Chen Xinyi, Zhou Zhangqiu, Wang Jieman, Zhang Yuanyuan, Zhang Shengpeng, He Hongliang, Kou Junping

2026, 24(5): 619-631. DOI: 10.1016/S1875-5364(26)61180-6

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Penicipenoids A−G, antioxidant and anti-inflammatory cadinane sesquiterpenoids with rearranged carbon skeletons from the marine sponge symbiotic Penicillium sp. 5975

Xie Dongdong, Li Peihai, Zhang Lu, Shang Ruyi, Li Jiaxin, Liu Kechun, Lin Houwen, Wang Shuping, Jiao Weihua

2026, 24(5): 632-640. DOI: 10.1016/S1875-5364(26)61181-8

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