中国天然药物

优先发表栏目展示本刊经同行评议确定正式录用的文章，这些文章目前处在编校过程，尚未确定卷期及页码，但可以根据DOI进行引用。

Multimethod-guided discovery of novel α-pyrone dimers with cardiomyocyte-protective activity against cold ischemia injury from the coral-derived Talaromyces sp. TJ403-AL05

Zeng Hanxiao, Wang Yaxing, Huang Chenmeng, Jiang Rui, Zhang Yongfei, Chai Zixue, Chi Jiangyang, Zhang Yonghui, Hu Zhengxi

DOI: 10.1016/S1875-5364(26)61207-1

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Discovery and synthesis of 3-amino glycyrrhizin derivative containing guanidyl with anti-colorectal cancer activity

Liu Jianrong, Zhang Jingke, Wu Tianbo, Jin Tingting, Zhao Quanyi, He Dian

DOI: 10.1016/S1875-5364(26)61210-1

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Astragalus polysaccharide ameliorates ischemic stroke via modulating the microbiota-gut-brain axis

Li Yu, Zhang Jing, Li Shuo, Zhu Rui, Ou Feifei, Xu He, Wang Yanan, Liu Yu, Tang Shihuan, Xu Jing

DOI: 10.1016/S1875-5364(26)61206-X

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Levistilide A restrains myocardial fibrosis by targeting malate dehydrogenase 2

Pan Ting, Cheng Yingying, Yan Yutian, Cao Wenjia, Jiang Qingjia, Li Ping, Zeng Hao

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Clavukellines A–N: dolabellane diterpenes from the soft coral Clavularia koellikeri

Lu Zhongyu, Zhu Xiao, Zhou Xin, Li Xiaobin, Han Xiao, Li Guoqiang

DOI: 10.1016/S1875-5364(26)61209-5

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Broad-spectrum anticoronaviral activity of the traditional herbal medicine Mahuangtang by targeting the multistep viral infection process: virus entry, Mpro, PLpro, RdRp and IFN induction

Yoon Jiwon, Jin Young-Hee, Kim Yeonhwa, Oh Eun Young, Park Sohyun, Min Jung Sun, Ha In Jin, Kim Sanghyun, Kim Hakjin, Lee Sang-Myeong, Kwon Sunoh

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Function-oriented synthesis of marine phidianidine derivatives as potent anti-MRSA agents

Wu Qiong, Yan Bingyuan, Qu Chen, Ma Chao, Li Xuwen

DOI: 10.1016/S1875-5364(26)61208-3

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Hederagenin attenuates renal senescence in diabetic kidney disease by inhibiting DNMT1-mediated Klotho DNA methylation

Luo Guanfeng, Liu Minyu, Yu Wenbin, Liu Huaxi, Zhou Jie, Li Dexian, Chen Fangxin, Yee Kwan Hiu, Tang Yang, You Yanting, Zhao Xiaoshan, Sun Xiaomin

DOI: 10.1016/S1875-5364(26)61205-8

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Angeloylgomisin O from YiQiFuMai lyophilized injection attenuates heart failure by inhibiting endothelial-mesenchymal transition via ACE2

Dai Sufang, Huang Zixuan, Liu Jincheng, Wu Lingling, Zhao Qingfei, Gong Shuaishuai, Zhang Yuanyuan, Yu Boyang, Li Fang, Kou Junping

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Mitochondria-targeted natural products with potential for the treatment of mitochondria-related diseases

Liu Xinyue, Li Hu, Wang Xuekai, Jiang Jiandong, Peng Zonggen

DOI: 10.1016/S1875-5364(26)61204-6

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The therapeutic potential of saponins for neurological diseases via the gut-brain axis

Wang Xuejing, Li Shiyin, Zhong Guangcheng, Zhang Ting, Chen Qini, Jing Shangwen, Liu Shan, Liu Junhui, Wang Qi

DOI: 10.1016/S1875-5364(26)61203-4

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Kaurepenoid A, a 2-nor-ent-kaurane diterpenoid with P-glycoprotein-mediated reversal of multidrug resistance activity from the fungus Bipolaris sp.

Shen Yong, Ding Nanjin, Zheng Meijia, Guo Tianyuan, Gu Xiaoxia, Liang Yu, Chen Chunmei, Li Qin, Zhang Yonghui, Zhu Hucheng

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“Marine Rule”: discovery of marine natural small molecule drug leads in China in the past decade

Chen Xinqi, Zhang Xi, Chen Chunmei, She Jianglian, Liu Yonghong, Zhang Cuixian, Cai Jian, Tang Lan, Zhou Xuefeng

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Natural cyclopeptide RA-V induces ER stress and promotes HRD1-mediated c-Myc degradation to inhibit pancreatic cancer stemness

Jiang Zhuangzhuang, Wu Yingwei, Cao Feng, Wang Jianghao, Ye Shuqing, Sui Yihang, Tan Ninghua

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Organ-on-a-Chip in Natural Product Research: Advancing Translational ADME, Efficacy and Safety Assessment

Hao Lijun, Ge Ye, Wang Tingting, Wang Guangji, Zhang Jingwei

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Hydrolyzed Ginsenosides of Panax notoginseng Flowers Attenuate Alcoholic Liver Disease by Inhibiting Oxidative Stress and Lipid Accumulation

Shen Hong, Ma Li-Juan, Wang Kang-Hui, Zhou Jun-Yi, Liu Jia-Yue, Wan Jian-Bo

DOI: 10.1016/S1875-5364(26)61118-1

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Quercetin Reverses the Breast Cancer-promoting Effects of Depression by Targeting PPARγ

Wu Yingchao, Liang Yuqi, Chen Liushan, Chen Jieting, Huang Junfeng, Yang Congwen, Zuo Qian, Chen Qianjun

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Traditional Chinese medicine-based drug delivery systems for anti-tumor therapies

Yang Lin, Wang Yani, Ye Xietao, Liu Qiaoming, Qu Ding, Chen Yan

DOI: 10.1016/S1875-5364(25)60860-0

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Research progress of small-molecule natural medicines for the treatment of ischemic stroke

Liu Kui, Wang Ling, Pang Tao

DOI: 10.1016/S1875-5364(24)60712-0

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Modulating the gut microbiota: a multi-target mechanism of traditional Chinese medicine for type 2 diabetes management

Ding Zhiping, Li Qunfang, Li Zi, Li Xiuyang

2026, 24(8): 897-911. DOI: 10.1016/S1875-5364(26)61200-9

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Naringenin ameliorates iron overload-associated osteoporosis via Tfeb/p62/Nrf2-mediated antioxidation

Pan Zhaofeng, Li Miao, Chen Baihao, Lu Jiaxin, Wang Fanchen, Meng Chenhui, Wang Xintian, Shao Min, He Qi, Wang Haibin

2026, 24(8): 912-928. DOI: 10.1016/S1875-5364(26)61193-4

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Patchouli alcohol protects against ulcerative colitis by alleviating ER stress and dysbiosis-mediated intestinal epithelial injury

Feng Sha, Li Wenhui, Zhang Xuqing, Lin Qiyue, Tian Juyi, Wang Ruolin, Yuan Lixia, Luo Piao, Zhang Qian

2026, 24(8): 929-940. DOI: 10.1016/S1875-5364(26)61194-6

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Genistein inhibits oxidative stress and alleviates vascular remodeling in hypertension through the GSK3β/FYN/Nrf2 pathway

Zhang Xiaotong, Xie Yixuan, Wu Zhijing, Xi Dongmei, Tang Na, Li Xinzhi, Ma Ketao

2026, 24(8): 941-955. DOI: 10.1016/S1875-5364(26)61195-8

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Self-assembled nanoaggregates in Wuzhuyu decoction: formation, absorption, transport, and alleviation of chronic migraine

Wang Qi, Guo Xiaomeng, Li Meijing, Nan Nan, Zhang Zekuan, Song Zhimin, Zhou Ziwei, Zhang Nan, He Rui, Li Jing, Zhao Hui, Liu Renhui, Qu Miao, Gong Muxin

2026, 24(8): 956-971. DOI: 10.1016/S1875-5364(26)61201-0

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Ramulus Mori alkaloids (SZ-A) sensitize triple-negative breast cancer to cisplatin via PLA2G2A-mediated ceramide metabolism

Chen Chao, Wan Mengqi, Zhu Zhixu, Xie Zhaoyu, Zhang Yu, Xu Tao, Meng Han, Wu Miaomiao, Gui Liangfeng, Lv Hongbo, Wang Guodong, Han Jun, Che Hui

2026, 24(8): 972-986. DOI: 10.1016/S1875-5364(26)61196-X

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Comorbid depression exacerbates Gelsemium elegans toxicity via disruption of the Clostridium-LCA-PXR-CYP3A11 metabolic axis

Zhang Fugui, Hu Wanyu, Zhao Xiaojie, Fu Bingxuan, Lin Yating, Xie Cong, Yang Ruopeng, Fu Yufang, Tan Weiling, Ye Ling

2026, 24(8): 987-998. DOI: 10.1016/S1875-5364(26)61197-1

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Identification and characterization of a promiscuous pentacyclic triterpenoid O-glycosyltransferase from Phytolacca americana

Zhang Yi, Wang Jinxin, Zhu Yiqing, Shen Yunheng, Dong Hongyuan, Yu Haiyang, An Zirui, Zhang Weidong, Zhang Yu, Hu Zhimin

2026, 24(8): 999-1005. DOI: 10.1016/S1875-5364(26)61198-3

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Discovery of dimeric costunolide-triazole conjugates as antihepatoma agents via integrating dimerization and molecular hybridization

Li Tianze, Jiang Chenxi, Li Qihao, Hu Min-min, Li Yabo, Yang Yao, Ma Yunbao, Wang Yongcui, Chen Jijun

2026, 24(8): 1006-1014. DOI: 10.1016/S1875-5364(26)61098-9

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Aspergillines E−L with TDPs inhibitory and combined anti-tumor activities from marine fungus Aspergillus sp. EGF 15-0-3 as environmental-induced products

Wei Xia, Guo Lishuang, Duan Xuewei, Zhang Zekun, An Linkun, Su Juncheng, Zhang Cuixian

2026, 24(8): 1015-1024. DOI: 10.1016/S1875-5364(26)61199-5

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