中国天然药物

优先发表栏目展示本刊经同行评议确定正式录用的文章，这些文章目前处在编校过程，尚未确定卷期及页码，但可以根据DOI进行引用。

Caftaric acid targets P2Y₁₄R to restore macrophage mitophagy and ameliorate sepsis

Wang Yilin, Ni Shurui, Li Zhuoting, Lu Yuhe, Zheng Kai, Shang Shenglan, Zhou Mengze

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Hyodeoxycholic acid ameliorates the senescence of cholangiocyte and inflammasome activation in cholestatic liver diseases by activating mitophagy

Fan Guifang, Mei Ting, Zhang Yinghao, Qin Wenqing, Guo Mengyu, Wang Hong, Li Xin, Li Xinxin, Liu Runping

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A santonin derivative, QX-6, alleviates ulcerative colitis by suppressing macrophage oxidative stress and inflammatory responses via modulation of ferroptosis-related signaling

Xiao Chuangmeng, Xie Xinyi, Lv Liqi, Duan Jiangling, Zhang Xiaokun, Li Yue, Wang Yanjun, Chen Hongzhuan, Sun Qingyan, Jin Jinmei, Luan Xin, Zhang Weidong

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Angeloylgomisin O from YiQiFuMai lyophilized injection attenuates heart failure by inhibiting endothelial-mesenchymal transition via ACE2

Dai Sufang, Huang Zixuan, Liu Jincheng, Wu Lingling, Zhao Qingfei, Gong Shuaishuai, Zhang Yuanyuan, Yu Boyang, Li Fang, Kou Junping

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Tracing a microbial vitamin from Bacteroides to metabolic health

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Essential Oils from Medicine and Food Homology Species: A Review of Constituents, Extraction, Bioactivities and Encapsulation

Wu Xinyi, Cao Yuhan, Hu Qin, Chen Junxi, Qiao Hongzhi, Feng Xue

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Onyjaposides A–J: flavonoid-derived amphiphiles from Onychium japonicum with anti-adipogenic activity via SIRT1 upregulation

Song Xiuqing, Yang Zhenyu, Wang Xin, Fan Yaoyue

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Hydrolyzed ginsenosides of Panax notoginseng flowers attenuate alcoholic liver disease by inhibiting oxidative stress and lipid accumulation

Shen Hong, Ma Lijuan, Wang Kanghui, Zhou Junyi, Liu Jiayue, Wan Jianbo

DOI: 10.1016/S1875-5364(26)61118-1

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Natural cyclopeptide RA-V induces ER stress and promotes HRD1-mediated c-Myc degradation to inhibit pancreatic cancer stemness

Jiang Zhuangzhuang, Wu Yingwei, Cao Feng, Wang Jianghao, Ye Shuqing, Sui Yihang, Tan Ninghua

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Shiwei Wendan Decoction alleviates atherosclerosis by suppressing endothelial inflammatory responses through the CHIP/ICAM1 axis

Wu Qiu, Jiang Miao, Zhang Zehua, Zhu Ziqi, Zhao Jingcheng, Sun Wancheng, Alimujiang Abudureyimu, Chen Du, Wang Hongzhi, Li Zhijian, Xu Dengqiu, Xie Xuejiao

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The antidepressant effect of SNS during mid- and late-adolescence in male rats: the role of AMPAR expression in the DRN

Zhou Liuchang, Luo Jieru, Yao Diya, Miao Yi, Liu Dan, Zhong Jialong, Deng Di, Shi Yafei, Zhang Rong

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Material-Form-Dependent Pharmacology of Oral Chinese Herbal Medicines in Colorectal Cancer: From Gastrointestinal Compartments to Tumor Ecosystems

Wei Yu, Feng Tingyu, Liu Jing-Li, Wang Wei

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Modulation of the AhR-IDO1-Kyn Axis by Toad Venom-Derived Hua-chan-su Promotes Anti-Tumor Immunity in Gastric Cancer

Wang Meng, Wang Hainan, Gu Wei, Zhang Mengxiao, Zhao Cheng, Wang Chunhua, Li Binjing, Li Yueyue, Wang Manman, Li Shanshan, Cheng Hui, Luo Chuan, He Dongbing, Li Qinglin

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Breyniaionoside D from Huai yam attenuates Alzheimer’s disease-like pathological changes associated with calcium dysregulation and neuroinflammatory signaling

Zeng Mengnan, Ye Kaili, Hao Fengxiao, Gu Danli, Wang Yuanyuan, Zhu Xingyu, Feng Weisheng, Zheng Xiaoke

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Mechanistic Studies of Traditional Chinese Medicine in Brain Disorders: Integrating Brain-Centric Target Identification and Brain–Body Crosstalk

Huang Fuyue, Cai Xiaoying, Zhu Qimeng, Hui Siwen, Li Xinyuan, Sun Chengpeng, Zheng Xiao

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Sesquiterpene lactones from the traditional Chinese medicine Eupatorium lindleyanum DC. and their preliminary protective effects against nano-SiO₂-induced injury

Xu Qing, Qing Mengli, Wang Chenhui, Dang Wen, Bai Xiaolin, Chen Gang, Zhou Di, Li Ning

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Mechanisms and translational targets of coronary microvascular endothelial injury in ischemic cardiomyopathy: from hypoxic stress to microenvironmental remodeling

Wang Tianen, Li Zhaoling, Shen Xiaoxuan, Chang Zhen, Luo Yalin, Sun Zijin, Zhang Zuhe, Chang, Tong Ying

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Self-Assembled Nanosystems Incorporating Traditional Chinese Medicine: Design, Function, and Therapeutic Performance

Qin Yi, Fan Yuanhe, Ye Heng, Wu Haoyuan, Zhang Qing, Zheng Caixia, Zhou Xunyong, Zhao Longshan, Guan Xuefeng

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Natural product screening strategies targeting the Nrf2 pathway: Current status, challenges, and future perspectives

Liu Haiyi, Su Erzheng, Duan Jin-ao, Xiao Ping

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Abnormal Mitochondrial Function in Cardiac Hypertrophy: From Mechanisms to Perspectives on Treatment with Traditional Chinese Medicine

Zhang Errui, Shi Junkai, Liu Guangyao, Zhu Yulong, VanDusen Nathan J., Tao Houchao, Gu Weiliang

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Natural Products Modulating Immune Checkpoints: From Medicinal Chemistry Insights to Translational Advances in Overcoming Tumor Immunotherapy Bottlenecks

Yuan Ting, Zhao Yichao, Ruan Bingxin, Chang Zhenhui, Jiang Feng

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Sasang Constitutional Phenotyping and the Evidence Gap in Precision Herbal Therapeutics: A Multi-Omics Roadmap

Amin Adnan

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Spatholobus suberectus Dunn Attenuates Hepatic Fibrogenesis by Disrupting the MFAP4 Mediated TGF-β1/LOXL1 Positive Feedback Loop

He Qingman, Yao Huan, Sui Yue, Gao Yongxiang, Chen Jianping

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Ecology-Guided and Technology-Enabled Strategies in the Discovery of Marine Natural Products for Drug Development

Feng Ran-Qi, Armel Kouame Kra Wilfried, Hao Yi, Osman Ezzat E. A., Guo Yue-Wei, Li Xu-Wen

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Multi-omics profiling elucidates the optimal cultivation time and chemical markers for animal-derived medicine Bungarus Parvus

Yu Kaiquan, Qiao Yajun, Wang Cuicui, Xu Meng, Wei Wenlong, Zhang Yesong, Li Tingwei, Bi Qirui, Zhang Jianqing, Guo Dean

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Levistilide A restrains myocardial fibrosis by targeting malate dehydrogenase 2

Pan Ting, Cheng Yingying, Yan Yutian, Cao Wenjia, Jiang Qingjia, Li Ping, Zeng Hao

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Organ-on-a-Chip in Natural Product Research: Advancing Translational ADME, Efficacy and Safety Assessment

Hao Lijun, Ge Ye, Wang Tingting, Wang Guangji, Zhang Jingwei

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Traditional Chinese medicine-based drug delivery systems for anti-tumor therapies

Yang Lin, Wang Yani, Ye Xietao, Liu Qiaoming, Qu Ding, Chen Yan

DOI: 10.1016/S1875-5364(25)60860-0

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Research progress of small-molecule natural medicines for the treatment of ischemic stroke

Liu Kui, Wang Ling, Pang Tao

DOI: 10.1016/S1875-5364(24)60712-0

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栏目

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Exosomes, a potential approach to enhance the therapeutic effects of traditional Chinese medicine

Huang Tengteng, Wang Ziyu, Zhao Yu, Fang Weirong

2026, 24(11): 1281-1293. DOI: 10.1016/S1875-5364(26)61220-4

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Icariin against neuroinflammation: emerging evidence for gut-brain axis modulation involving short-chain fatty acids, vagal signaling, and extracellular vesicles

Wu Changzheng, Guo Lijiao, Sun Xiaoyu, Zhu Jinpu, Zhao Zhehao, Qi Shuo, Li Yaru, Li Hongyang, Zhao Renshuang, Xiu Zhiru, Zhu Guangze, Li Yiquan

2026, 24(11): 1294-1309. DOI: 10.1016/S1875-5364(26)61221-6

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Quercetin reverses the breast cancer-promoting effects of depression by targeting PPARγ

Wu Yingchao, Liang Yuqi, Chen Liushan, Chen Jieting, Huang Junfeng, Yang Congwen, Zuo Qian, Chen Qianjun

2026, 24(11): 1310-1321. DOI: 10.1016/S1875-5364(26)61222-8

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Artemisinin derived from Artemisia annua L. promotes thrombopoiesis via targeting FLT3: a novel strategy for thrombocytopenia management

Mei Xinyue, Liu Sheng, Zhou Linglin, Wang Yiling, Hu Tianci, Qi Xiao, Li Fengyu, Huang Feihong, Peng Wenchuan, Shen Xinyue, Huang Siyu, Lei Mengying, Wu Anguo, Wu Jianming, Luo Jiesi, Wang Long

2026, 24(11): 1322-1342. DOI: 10.1016/S1875-5364(26)61223-X

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Neferine sensitizes oral squamous cell carcinoma to cisplatin by disrupting the CCDC43-PNKP interaction

Lin Yangfeng, Zheng Xiongzhou, Tang Yue, Chen Jianguang, Chen Xiao, Liang Zixi, Lin Xian, Zhu Xiaofeng

2026, 24(11): 1343-1353. DOI: 10.1016/S1875-5364(26)61224-1

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Quercetin activates lysosomal function to ameliorate neuroinflammation and cognitive deficits in chronic cerebral hypoperfusion

Chen Yao, Jiang Yibin, Song Tang, Chen Yongxin, Li Jing, Zhi Ning, Wei Hongqiao, Huang Kaiyong, Huang Xiaowei, Lu Guodong, Zhou Jing

2026, 24(11): 1354-1365. DOI: 10.1016/S1875-5364(26)61225-3

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Isoimperatorin regulates hepatic fibrosis through LXRα/β-HMGB1/NLRP3 axis: insights into the apoptosis of activated hepatic stellate cells in hepatic microenvironment

Liu Saihu, Xuan Meiyan, Gao Chong, Wang Chenyu, Lian Lihua, Nan Jixing, Cui Zhenyu, Wu Yanling

2026, 24(11): 1366-1378. DOI: 10.1016/S1875-5364(26)61226-5

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Brevilin A induces mitochondrial dysfunction and endoplasmic reticulum stress in breast cancer through WWP2-mediated KLF5 degradation

Si Yuan, Peng Wenkang, Liu Ling, Tan Miao, Wang Sicheng, Zheng Chengling, Peng Peng, Xia Qiang, Zheng Kainan, Liu Xuewen, Liu Ying, Tan Yan

2026, 24(11): 1379-1391. DOI: 10.1016/S1875-5364(26)61227-7

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CCA, a cassane diterpene from Caesalpinia bonduc ameliorates cognition impairment in Alzheimer’s disease mice by regulating neuroinflammation and autophagy

Zhou Jiayu, Zhang Wei, Yang Yiren, Jin Yue, Li Xiaoyu, Wang Yuxin, Lu Hongyuan, Gao Huiyuan, Jiang Xiaowen

2026, 24(11): 1392-1408. DOI: 10.1016/S1875-5364(26)61228-9

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