中国天然药物

优先发表栏目展示本刊经同行评议确定正式录用的文章，这些文章目前处在编校过程，尚未确定卷期及页码，但可以根据DOI进行引用。

Kaurepenoid A, a 2-nor-ent-kaurane diterpenoid with P-glycoprotein-mediated reversal of multidrug resistance activity from the fungus Bipolaris sp.

Shen Yong, Ding Nanjin, Zheng Meijia, Guo Tianyuan, Gu Xiaoxia, Liang Yu, Chen Chunmei, Li Qin, Zhang Yonghui, Zhu Hucheng

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Neferine sensitizes oral squamous cell carcinoma to cisplatin by disrupting the CCDC43-PNKP interaction

Lin Yangfeng, Zheng Xiongzhou, Tang Yue, Chen Jianguang, Chen Xiao, Liang Zixi, Lin Xian, Zhu Xiaofeng

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Hyperperins A–X, fusicoccane diterpenoids including an unreported 5/7/5/3 tetracyclic carbon skeleton from Hypoestes purpurea and their T-type calcium channel inhibitory activity

Ding Linfen, Hu Ming, Wei Qiaoling, Yin Shihuan, Wang Xinying, Sai Lu, Li Wenyan, Wu Xingde

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Targeting senescence-associated fibrotic signatures identifies syringin as an effective modulator of the ATR/CHK1–p53 axis in idiopathic pulmonary fibrosis

Wang Yuyang, Yin Guanghui, Niu Mixing, Wang Wei, Liao Zhenyun, Yang Lei, Wu Chunli, Cao Yu, Gao Kai, Dong Zhaoxing

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Single-cell analysis reveals synergistic therapeutic mechanisms of Shenqi Fuzheng formula against acute myocardial infarction

Wang Menglei, Li Xiang, Gao Meng, Zhu Bingjie, Wei Tiezhu, Huang Wenhua, Fan Xiaohui, Liao Jie

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Icariin enhances PINK1-associated mitophagy to attenuate NLRP3/GSDMD-related microglial pyroptosis and cognitive impairment in Alzheimer’s disease

Fan Longmin, Jiang Haitao, Yi Min, Peng Weijun, Zhang Zheyu

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Broad-spectrum anticoronaviral activity of the traditional herbal medicine Mahuangtang by targeting the multistep viral infection process: virus entry, Mpro, PLpro, RdRp and IFN induction

Yoon Jiwon, Jin Young-Hee, Kim Yeonhwa, Oh Eun Young, Park Sohyun, Min Jung Sun, Ha In Jin, Kim Sanghyun, Kim Hakjin, Lee Sang-Myeong, Kwon Sunoh

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Mechanisms and translational targets of coronary microvascular endothelial injury in ischemic cardiomyopathy: from hypoxic stress to microenvironmental remodeling

Wang Tianen, Li Zhaoling, Shen Xiaoxuan, Chang Zhen, Luo Yalin, Sun Zijin, Zhang Zuhe, Chang, Tong Ying

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Self-Assembled Nanosystems Incorporating Traditional Chinese Medicine: Design, Function, and Therapeutic Performance

Qin Yi, Fan Yuanhe, Ye Heng, Wu Haoyuan, Zhang Qing, Zheng Caixia, Zhou Xunyong, Zhao Longshan, Guan Xuefeng

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Natural product screening strategies targeting the Nrf2 pathway: Current status, challenges, and future perspectives

Liu Haiyi, Su Erzheng, Duan Jin-ao, Xiao Ping

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Abnormal Mitochondrial Function in Cardiac Hypertrophy: From Mechanisms to Perspectives on Treatment with Traditional Chinese Medicine

Zhang Errui, Shi Junkai, Liu Guangyao, Zhu Yulong, VanDusen Nathan J., Tao Houchao, Gu Weiliang

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Natural Products Modulating Immune Checkpoints: From Medicinal Chemistry Insights to Translational Advances in Overcoming Tumor Immunotherapy Bottlenecks

Yuan Ting, Zhao Yichao, Ruan Bingxin, Chang Zhenhui, Jiang Feng

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Sasang Constitutional Phenotyping and the Evidence Gap in Precision Herbal Therapeutics: A Multi-Omics Roadmap

Amin Adnan

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Spatholobus suberectus Dunn Attenuates Hepatic Fibrogenesis by Disrupting the MFAP4 Mediated TGF-β1/LOXL1 Positive Feedback Loop

He Qingman, Yao Huan, Sui Yue, Gao Yongxiang, Chen Jianping

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Ecology-Guided and Technology-Enabled Strategies in the Discovery of Marine Natural Products for Drug Development

Feng Ran-Qi, Armel Kouame Kra Wilfried, Hao Yi, Osman Ezzat E. A., Guo Yue-Wei, Li Xu-Wen

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Isoimperatorin regulates hepatic fibrosis through LXRα/β-HMGB1/NLRP3 axis: insights into the apoptosis of activated hepatic stellate cells in hepatic microenvironment

Liu Saihu, Xuan Meiyan, Gao Chong, Wang Chenyu, Lian Lihua, Nan Jixing, Cui Zhenyu, Wu Yanling

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Brevilin A induces mitochondrial dysfunction and endoplasmic reticulum stress in breast cancer through WWP2-mediated KLF5 degradation

Si Yuan, Peng Wenkang, Liu Ling, Tan Miao, Wang Sicheng, Zheng Chengling, Peng Peng, Xia Qiang, Zheng Kainan, Liu Xuewen, Liu Ying, Tan Yan

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Exosomes, a potential approach to enhance the therapeutic effects of traditional Chinese medicine

Huang Tengteng, Wang Ziyu, Zhao Yu, Fang Weirong

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Quercetin reverses the breast cancer-promoting effects of depression by targeting PPARγ

Wu Yingchao, Liang Yuqi, Chen Liushan, Chen Jieting, Huang Junfeng, Yang Congwen, Zuo Qian, Chen Qianjun

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Multi-omics profiling elucidates the optimal cultivation time and chemical markers for animal-derived medicine Bungarus Parvus

Yu Kaiquan, Qiao Yajun, Wang Cuicui, Xu Meng, Wei Wenlong, Zhang Yesong, Li Tingwei, Bi Qirui, Zhang Jianqing, Guo Dean

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Gypensapogenin I ameliorates liver fibrosis by targeting MST1, restoring Hippo pathway homeostasis, and inhibiting HSCs activation

Huang Kexin, Chen Xiaoxu, Pei Hanbo, Yang Nan, Miao Yuxin, Zhang Xiaoshu, Yue Jiayin

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Artemisinin derived from Artemisia annua L. promotes thrombopoiesis via targeting FLT3: a novel strategy for thrombocytopenia management

Mei Xinyue, Liu Sheng, Zhou Linglin, Wang Yiling, Hu Tianci, Qi Xiao, Li Fengyu, Huang Feihong, Peng Wenchuan, Shen Xinyue, Huang Siyu, Lei Mengying, Wu Anguo, Wu Jianming, Luo Jiesi, Wang Long

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Data mining and multi-omics profiling to reveal the mechanisms of cold/hot property of traditional Chinese medicine in Alzheimer’s disease treatment

Zhu Mingtao, Wang Yu, Tang Haipeng, Sun Yanping, Feng XiaoTao, Wang Qiuhong, Kuang Haixue

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From bench to beside: luteolin’s therapeutic promise in neurological disorders

Zhu Wenjun, Yuan Naijun, Tang Manshi, She Kaijie, Chen Man, Huang Minyi, Feng Ruotong, Ma Qingyu, Chen Jiaxu

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CCA, a cassane diterpene from Caesalpinia bonduc ameliorates cognition impairment in Alzheimer’s disease mice by regulating Neuroinflammation and Autophagy

Zhou Jiayu, Zhang Wei, Yang Yiren, Jin Yue, Li Xiaoyu, Wang Yuxin, Lu Hongyuan, Gao Huiyuan, Jiang Xiaowen

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Icariin against neuroinflammation: emerging evidence for gut-brain axis modulation involving short-chain fatty acids, vagal signaling, and extracellular vesicles

Wu Changzheng, Guo Lijiao, Sun Xiaoyu, Zhu Jinpu, Zhao Zhehao, Qi Shuo, Li Yaru, Li Hongyang, Zhao Renshuang, Xiu Zhiru, Zhu Guangze, Li Yiquan

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Quercetin Activates Lysosomal Function to Ameliorate Neuroinflammation and Cognitive Deficits in Chronic Cerebral Hypoperfusion

Chen Yao, Jiang Yi-Bin, Song Tang, Chen Yong-Xin, Li Jing, zhi Ning, Wei Hong-Qiao, Huang Kai-Yong, Huang Xiao-Wei, Lu Guo-Dong, Zhou Jing

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Levistilide A restrains myocardial fibrosis by targeting malate dehydrogenase 2

Pan Ting, Cheng Yingying, Yan Yutian, Cao Wenjia, Jiang Qingjia, Li Ping, Zeng Hao

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Angeloylgomisin O from YiQiFuMai lyophilized injection attenuates heart failure by inhibiting endothelial-mesenchymal transition via ACE2

Dai Sufang, Huang Zixuan, Liu Jincheng, Wu Lingling, Zhao Qingfei, Gong Shuaishuai, Zhang Yuanyuan, Yu Boyang, Li Fang, Kou Junping

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Natural cyclopeptide RA-V induces ER stress and promotes HRD1-mediated c-Myc degradation to inhibit pancreatic cancer stemness

Jiang Zhuangzhuang, Wu Yingwei, Cao Feng, Wang Jianghao, Ye Shuqing, Sui Yihang, Tan Ninghua

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Organ-on-a-Chip in Natural Product Research: Advancing Translational ADME, Efficacy and Safety Assessment

Hao Lijun, Ge Ye, Wang Tingting, Wang Guangji, Zhang Jingwei

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Hydrolyzed Ginsenosides of Panax notoginseng Flowers Attenuate Alcoholic Liver Disease by Inhibiting Oxidative Stress and Lipid Accumulation

Shen Hong, Ma Li-Juan, Wang Kang-Hui, Zhou Jun-Yi, Liu Jia-Yue, Wan Jian-Bo

DOI: 10.1016/S1875-5364(26)61118-1

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Traditional Chinese medicine-based drug delivery systems for anti-tumor therapies

Yang Lin, Wang Yani, Ye Xietao, Liu Qiaoming, Qu Ding, Chen Yan

DOI: 10.1016/S1875-5364(25)60860-0

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Research progress of small-molecule natural medicines for the treatment of ischemic stroke

Liu Kui, Wang Ling, Pang Tao

DOI: 10.1016/S1875-5364(24)60712-0

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“Marine Rule”: discovery of marine natural small molecule drug leads in China in the past decade

Chen Xinqi, Zhang Xi, Chen Chunmei, She Jianglian, Liu Yonghong, Zhang Cuixian, Cai Jian, Tang Lan, Zhou Xuefeng

2026, 24(9): 1025-1049. DOI: 10.1016/S1875-5364(26)61202-2

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The therapeutic potential of saponins for neurological diseases via the gut-brain axis

Wang Xuejing, Li Shiyin, Zhong Guangcheng, Zhang Ting, Chen Qini, Jing Shangwen, Liu Shan, Liu Junhui, Wang Qi

2026, 24(9): 1050-1067. DOI: 10.1016/S1875-5364(26)61203-4

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Mitochondria-targeted natural products with potential for the treatment of mitochondria-related diseases

Liu Xinyue, Li Hu, Wang Xuekai, Jiang Jiandong, Peng Zonggen

2026, 24(9): 1068-1080. DOI: 10.1016/S1875-5364(26)61204-6

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Astragalus polysaccharide ameliorates ischemic stroke via modulating the microbiota-gut-brain axis

Li Yu, Zhang Jing, Li Shuo, Zhu Rui, Ou Feifei, Xu He, Wang Yanan, Liu Yu, Tang Shihuan, Xu Jing

2026, 24(9): 1081-1093. DOI: 10.1016/S1875-5364(26)61206-X

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Hederagenin attenuates renal senescence in diabetic kidney disease by inhibiting DNMT1-mediated Klotho DNA methylation

Luo Guanfeng, Liu Minyu, Yu Wenbin, Liu Huaxi, Zhou Jie, Li Dexian, Chen Fangxin, Yee Kwan Hiu, Tang Yang, You Yanting, Zhao Xiaoshan, Sun Xiaomin

2026, 24(9): 1094-1109. DOI: 10.1016/S1875-5364(26)61205-8

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Multimethod-guided discovery of novel α-pyrone dimers with cardiomyocyte-protective activity against cold ischemia injury from the coral-derived Talaromyces sp. TJ403-AL05

Zeng Hanxiao, Wang Yaxing, Huang Chenmeng, Jiang Rui, Zhang Yongfei, Chai Zixue, Chi Jiangyang, Zhang Yonghui, Hu Zhengxi

2026, 24(9): 1110-1122. DOI: 10.1016/S1875-5364(26)61207-1

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Clavukellines A–N: dolabellane diterpenes from the soft coral Clavularia koellikeri

Lu Zhongyu, Zhu Xiao, Zhou Xin, Li Xiaobin, Han Xiao, Li Guoqiang

2026, 24(9): 1123-1128. DOI: 10.1016/S1875-5364(26)61209-5

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Discovery and synthesis of 3-amino glycyrrhizin derivative containing guanidyl with anti-colorectal cancer activity

Liu Jianrong, Zhang Jingke, Wu Tianbo, Jin Tingting, Zhao Quanyi, He Dian

2026, 24(9): 1129-1145. DOI: 10.1016/S1875-5364(26)61210-1

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Function-oriented synthesis of marine phidianidine derivatives as potent anti-MRSA agents

Wu Qiong, Yan Bingyuan, Qu Chen, Ma Chao, Li Xuwen

2026, 24(9): 1146-1152. DOI: 10.1016/S1875-5364(26)61208-3

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