Research topic: Researches on the fungal bioactive secondary metabolites
Research topic: Researches on the fungal bioactive secondary metabolites
Guest editor: Dr. Guo-Dong Chen has been working in the institute of traditional Chinese medicine & natural products, Jinan University since 2015. His current research focuses on searching for bioactive substances from natural products. Up to now, he has authored 37 scientific papers in SCI journals including Nat. Commun., Org. Lett., Chem. Commun., J. Nat. Prod., etc., and got 10 licensed patents.
[Abstract] Fungi are bound up with human life. Although some species are pathogens threaten to human and plants, most of them are beneficial to human, which have been used in food (such as making of cheeses and bread), drinks (such as making of beer and wine), and medicines (e.g. Ganoderma Lucidum) for thousands of years. They have played a key role in satisfying people’s demand for healthy.
Cite this article as: CHEN Guo-Dong, HU Dan, GAO Hao, YAO Xin-Sheng. The importance of researches on the fungal bioactive secondary metabolites in developing the comprehensive health industry [J]. Chin J Nat Med, 2020, 18(4): 241-242.
[Abstract] Mycosphazine A ( 1 ), a new iron(III) chelator of coprogen-type siderophore, and mycosphamide A ( 2 ), a new cyclic amide benzoate, together with six known aryl amides ( 3−8 ), were isolated from the fermentation broth of the deep-sea-derived fungus Mycosphaerella sp. SCSIO z059. Alkaline hydrolysis of 1 afforded a new epimer of dimerum acid, mycosphazine B ( 1a ), and a new bi-fusarinine-type siderophore, mycosphazine C ( 1b ). The planar structures of the new compounds were elucidated by extensive spectroscopic data analysis. The absolute configurations of amino acid residues in 1a and 1b were determined by acid hydrolysis. And the absolute configuration of 2 was established by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Compound 1 is the first siderophore-Fe(III) chelator incorporating both L-ornithine and D-ornithine unites. Compounds 3−8 were reported as natural products for the first time, and the 1H and 13C NMR data of 6 and 8 were assigned for the first time. Compounds 1 and 1a could greatly promote the biofilm formation of bacterium Bacillus amyloliquefaciens with the rate of about 249% and 524% at concentration of 100 μg·mL−1, respectively.
Cite this article as: HUANG Zhong-Hui, LIANG Xiao, QI Shu-Hua. A new iron(III) chelator of coprogen-type siderophore from the deep-sea-derived fungus Mycosphaerella sp. SCSIO z059 [J]. Chin J Nat Med, 2020, 18(4): 243-249.
Title: Four new steroids from the marine soft coral-derived fungus Penicillium sp. SCSIO41201
[Abstract] Penicildiones A−D ( 1 − 4 ), four new steroids derivatives together with three known compounds including 16α-methylpregna-17α,19-dihydroxy-(9,11)-epoxy-4-ene-3,18-dione-20-acetoxy ( 5 ), stachybotrylactone B ( 6 ) and stachybotrin ( 7 ) were isolated from the soft coral-derived fungus Penicillium sp. SCSIO41201, cultured in the 1% NaCl PDB substrate. Their structures were determined through spectroscopic methods and X-ray crystallography. Biological evaluation results revealed that 6 exhibited significant cytotoxic activity against HL-60, K562, MOLT-4, ACHN, 786-O, and OS-RC-2 cell lines with IC50 values of 5.23, 4.12, 4.31, 23.55, 7.65 and 10.81 μmol·L−1, respectively, while other compounds showed weak or no cytotoxicity at 50 μmol·L−1.
Cite this article as: LONG Jie-Yi, WANG Jun-Feng, LIAO Sheng-Rong, LIN Xiu-Ping, ZHOU Xue-Feng, LI Yun-Qiu, YANG Bin, LIU Yong-Hong. Four new steroids from the marine soft coral-derived fungus Penicillium sp. SCSIO41201 [J].Chin J Nat Med, 2020, 18(4): 250-255.
Title: Three new isocoumarin derivatives from the mangrove endophytic fungus Penicillium sp. YYSJ-3
[Abstract] Three new isocoumarin derivatives, (S)-6,8-dihydroxy-5-(methoxymethyl)-3,7-dimethylisochroman-1-one ( 1 ), (S)-6,8-dihydroxy-3,5,7-trimethyl-isochroman-1-one ( 2 ) and (R)-2-chloro-3-(8-hydroxy-6-methoxy-1-oxo-1H-isochromen-3-yl) propyl acetate ( 3 ), along with four known compounds ( 4 – 7 ) were isolated from a mangrove endophytic fungus Penicillium sp. YYSJ-3. Their structures were established on the basis of the extensive spectroscopic data and HR-ESI-MS analysis. The absolute configurations of 1 – 3 were further determined by X-ray diffraction analysis and optical rotations. Compounds 3 , 6 and 7 showed promising inhibitory activity against α-glucosidase, which were stronger than that of the positive control 1-deoxynojirimycin (IC50 141.2 μmol·L−1).
Cite this article as: QIU Pei, CAI Run-Lin, LI Lin, SHE Zhi-Gang. Three new isocoumarin derivatives from the mangrove endophytic fungus Penicillium sp. YYSJ-3 [J]. Chin J Nat Med, 2020, 18(4): 256-260.
[Abstract] Two new caryophyllene-type sesquiterpenoids, pestathenols A ( 1 ) and B ( 2 ) and one new α-furanone, pestatheranone A ( 6 ), along with five known compounds ( 3 – 5 , 7 and 8 ) have been isolated from the crude extract of the plant endophytic fungus Pestalotiopsis theae. Their structures were unambiguously established by extensive spectroscopic analyses. The absolute configuration of the 5,6-diol moiety in 1 was assigned using Snatzke’s method. Compounds 1 and 2 showed weak cytotoxicity against HeLa cell line.
Cite this article as: GUO Long-Fang, LIU Gao-Ran, LIU Ling. Caryophyllene-type sesquiterpenoids and α-furanones from the plant endophytic fungus Pestalotiopsis theae [J]. Chin J Nat Med, 2020, 18(4): 261-267.
Title: New meroterpenoid compounds from the culture of mushroom Panus lecomtei
[Abstract] Two new meroterpenoid compounds ( 1 and 2 ) together with five known meroterpenoid derivatives ( 3 – 7 ) were isolated from solid culture of mushroom Panus lecomtei. The structures of new compounds were confirmed by the analysis of NMR and HR-ESI-MS spectroscopic data. The biosynthetic pathway of 1 – 7 was postulated. All isolated compounds were evaluated for antibacterial activities against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa and Bacillus Calmette–Guérin. Compound 3 exhibited weak antibacterial activity against Bacillus Calmette–Guérin with the inhibition rate of 83.6% at 100 μmol·L−1. Other compounds showed no antibacterial activities against all tested pathogens at 100 μmol·L−1.
Cite this article as: WANG Si-Xian, ZHAO Rui-Lin, GUO Cui, CHEN Bao-Song, DAI Huan-Qin, LIU Gao-Qiang, LIU Hong-Wei. New meroterpenoid compounds from the culture of mushroom Panus lecomtei [J]. Chin J Nat Med, 2020, 18(4): 268-272.
