<i>Salvia miltiorrhiza</i>:Traditional medicinal uses, chemistry, and pharmacology

SU Chun-Yan; MING Qian-Liang; RAHMAN Khalid; HAN Ting; QIN Lu-Ping

Volume 13 Issue 3

Mar. 2015

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Article Contents

Article Navigation > Chinese Journal of Natural Medicines > 2015 > 13(3): 163-182

Citation:

Salvia miltiorrhiza:Traditional medicinal uses, chemistry, and pharmacology

1.
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;
2.
Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, China;
3.
Department of Pharmacognosy, School of Pharmacy, Third Military Medical University, Chongqing 400038, China;
4.
Faculty of Science, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK

Corresponding author:
Received Date: 18-Apr.-2014

Fund Project: This work was supported by the Young Scientist Special Project of the National High Technology Research and Development Program of China (No. 2014AA020508) and National Nature Science Foundation of China (No. 81473301).

Abstract

Salvia miltiorrhiza Bunge (SM) is a very popular medicinal plant that has been extensively applied for many years to treat various diseases, especially coronary heart diseases and cerebrovascular diseases, either alone or in combination with other Chinese plant-based medicines. Although a large number of studies on SM have been performed, they are scattered across a variety of publications. The present review is an up-to-date summary of the published scientific information about the traditional uses, chemical constituents, pharmacological effects, side effects, and drug interactions with SM, in order to lay the foundation for further investigations and better utilization of SM. SM contains diverse chemical components including diterpenoid quinones, hydrophilic phenolic acids, and essential oils. Many pharmacological studies have been done on SM during the last 30 years, focusing on the cardiovascular and cerebrovascular effects, and the antioxidative, neuroprotective, antifibrotic, anti-inflammatory, and antineoplastic activities. The research results strongly support the notion that SM has beneficial therapeutic properties and has a potential of being an effective adaptogenic remedy.
- Danshen,
- Cardiovascular diseases,
- Antitumor,
- Side effect,
- Review

References

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沈阳化工大学材料科学与工程学院沈阳 110142

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Salvia miltiorrhiza:Traditional medicinal uses, chemistry, and pharmacology

Corresponding author:

1. Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;

2. Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, China;

3. Department of Pharmacognosy, School of Pharmacy, Third Military Medical University, Chongqing 400038, China;

4. Faculty of Science, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK

Received Date: 2014-04-18

Fund Project: This work was supported by the Young Scientist Special Project of the National High Technology Research and Development Program of China (No. 2014AA020508) and National Nature Science Foundation of China (No. 81473301).

Abstract: Salvia miltiorrhiza Bunge (SM) is a very popular medicinal plant that has been extensively applied for many years to treat various diseases, especially coronary heart diseases and cerebrovascular diseases, either alone or in combination with other Chinese plant-based medicines. Although a large number of studies on SM have been performed, they are scattered across a variety of publications. The present review is an up-to-date summary of the published scientific information about the traditional uses, chemical constituents, pharmacological effects, side effects, and drug interactions with SM, in order to lay the foundation for further investigations and better utilization of SM. SM contains diverse chemical components including diterpenoid quinones, hydrophilic phenolic acids, and essential oils. Many pharmacological studies have been done on SM during the last 30 years, focusing on the cardiovascular and cerebrovascular effects, and the antioxidative, neuroprotective, antifibrotic, anti-inflammatory, and antineoplastic activities. The research results strongly support the notion that SM has beneficial therapeutic properties and has a potential of being an effective adaptogenic remedy.

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Reference (102)

[1]	Lam FFY, Yeung JHK, Cheung JHY, et al. Pharmacological evidence for calcium channel inhibition by Danshen (Salvia miltiorrhiza) on rat isolated femoral artery[J]. J Cardiovasc Pharmacol, 2006, 47(1):139-145.
[2]	Editorial Committee of Flora of China. Flora of China[M]. Science Press, 1994:212.
[3]	Zhou Y, Li W, Xu L, et al. In Salvia miltiorrhiza, phenolic acids possess protective properties against amyloid -induced cytotoxicity, and tanshinones act as acetylcholinesterase inhibitors[J]. Environ Toxicol Pharmacol, 2011, 31(3):443-452.
[4]	Wong KKK, Ho MTW, Lin HQ, et al. Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task[J]. Planta Med, 2010, 76(3):228-234.
[5]	Zhang HN, An CN, Pu XP. Protocatechuic acid inhibits neurotoxicity induced by MPTP in vivo[J]. Neurosci Lett, 2010, 474(2):99-103.
[6]	Kang DG, Oh H, Sohn EJ, et al. Lithospermic acid B isolated from Salvia miltiorrhiza ameliorates ischemia/reperfusioninduced renal injury in rats[J]. Life Sci, 2004, 75(15):1801-1816.
[7]	Lin YL, Wu CH, Luo MH, et al. In vitro protective effects of salvianolic acid B on primary hepatocytes and hepatic stellate cells[J]. J Ethnopharmacol, 2006, 105(1):215-222.
[8]	Wu Z, Wen T, Tan Y, et al. Effects of salvianolic acid A on oxidative stress and liver injury induced by carbon tetrachloride in rats[J]. Basic Clin Pharmacol, 2007, 100(2):115-120.
[9]	Zhang HS, Wang SQ. Salvianolic acid B from Salvia miltiorrhiza inhibits tumor necrosis factor- (TNF-)-induced MMP-2 upregulation in human aortic smooth muscle cells via suppression of NAD(P)H oxidase-derived reactive oxygen species[J]. J Mol Cell Cardiol, 2006, 41(1):138-148.
[10]	Tian X, Xue W, Ding X. Application of Danshen injection on early stage of renal transplantation[J]. Chin J Integr Med, 2005, 25(5):404-407.
[11]	Cheng TO. Danshen:a popular Chinese cardiac herbal drug[J]. J Am Coll Cardiol, 2006, 47(7):1498-1498.
[12]	Zhou L, Zuo Z, Chow MSS. Danshen:an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use[J]. J Clin Pharmacol, 2005, 45(12):1345-1359.
[13]	Editorial Committee of Flora of Anhui. Flora of Anhui[M]. Anhui Science Technology Publishing House, 1986:276.
[14]	Yang Y, Wang ZR, Xu BL, et al. A comparative study of cyclosporin A, Danshen and verapamil on inhibiting epithelium cell proliferation[J]. Chin Pharmacol Bull, 1997, 13(4):370-372.
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