“Omics” in pharmaceutical research:overview, applications, challenges, and future perspectives

YAN Shi-Kai; LIU Run-Hui; JIN Hui-Zi; LIU Xin-Ru; YE Ji; SHAN Lei; ZHANG Wei-Dong

Volume 13 Issue 1

Jan. 2015

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Article Contents

Article Navigation > Chinese Journal of Natural Medicines > 2015 > 13(1): 3-21

Citation:

“Omics” in pharmaceutical research:overview, applications, challenges, and future perspectives

1.
School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China;
2.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China;
3.
Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China

Corresponding author:
Received Date: 13-Oct.-2014

Fund Project: The work was supported by Professor of Chang Jiang Scholars Program, NSFC (No. 81230090), Shanghai Leading Academic Discipline Project (B906), Key laboratory of drug research for special environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (No. 10DZ2251300), the Scientific Foundation of Shanghai, China (Nos. 12401900801, 13401900 101), National Major Project of China (No. 2011ZX09307-002-03) and the National Key Technology R&D Program of China (No. 2012BAI29B06)

Abstract

In the post-genomic era, biological studies are characterized by the rapid development and wide application of a series of omics technologies, including genomics, proteomics, metabolomics, transcriptomics, lipidomics, cytomics, metallomics, ionomics, interactomics, and phenomics. These omics are often based on global analyses of biological samples using high through-put analytical approaches and bioinformatics and may provide new insights into biological phenomena. In this paper, the development and advances in these omics made in the past decades are reviewed, especially genomics, transcriptomics, proteomics and metabolomics; the applications of omics technologies in pharmaceutical research are then summarized in the fields of drug target discovery, toxicity evaluation, personalized medicine, and traditional Chinese medicine; and finally, the limitations of omics are discussed, along with the future challenges associated with the multi-omics data processing, dynamics omics analysis, and analytical approaches, as well as amenable solutions and future prospects.
- Omics,
- Genomics,
- Transcriptomics,
- Proteomics,
- Metabolomics,
- Target Discovery,
- Toxicity Assessment,
- Personalized Medicine,
- Traditional Chinese Medicine

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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“Omics” in pharmaceutical research:overview, applications, challenges, and future perspectives

Corresponding author:

1. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China;

2. School of Pharmacy, Second Military Medical University, Shanghai 200433, China;

3. Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China

Received Date: 2014-10-13

Fund Project: The work was supported by Professor of Chang Jiang Scholars Program, NSFC (No. 81230090), Shanghai Leading Academic Discipline Project (B906), Key laboratory of drug research for special environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (No. 10DZ2251300), the Scientific Foundation of Shanghai, China (Nos. 12401900801, 13401900 101), National Major Project of China (No. 2011ZX09307-002-03) and the National Key Technology R&D Program of China (No. 2012BAI29B06)

Abstract: In the post-genomic era, biological studies are characterized by the rapid development and wide application of a series of omics technologies, including genomics, proteomics, metabolomics, transcriptomics, lipidomics, cytomics, metallomics, ionomics, interactomics, and phenomics. These omics are often based on global analyses of biological samples using high through-put analytical approaches and bioinformatics and may provide new insights into biological phenomena. In this paper, the development and advances in these omics made in the past decades are reviewed, especially genomics, transcriptomics, proteomics and metabolomics; the applications of omics technologies in pharmaceutical research are then summarized in the fields of drug target discovery, toxicity evaluation, personalized medicine, and traditional Chinese medicine; and finally, the limitations of omics are discussed, along with the future challenges associated with the multi-omics data processing, dynamics omics analysis, and analytical approaches, as well as amenable solutions and future prospects.

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“Omics” in pharmaceutical research:overview, applications, challenges, and future perspectives

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通讯作者: 陈斌, bchen63@163.com

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