Volume 13 Issue 1
Jan.  2015
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Article Contents


“Omics” in pharmaceutical research:overview, applications, challenges, and future perspectives

  • Corresponding author:
  • Received Date: 13-Oct.-2014
    Fund Project: The work was supported by Professor of Chang Jiang Scholars Program, NSFC (No. 81230090), Shanghai Leading Academic Discipline Project (B906), Key laboratory of drug research for special environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (No. 10DZ2251300), the Scientific Foundation of Shanghai, China (Nos. 12401900801, 13401900 101), National Major Project of China (No. 2011ZX09307-002-03) and the National Key Technology R&D Program of China (No. 2012BAI29B06)
  • In the post-genomic era, biological studies are characterized by the rapid development and wide application of a series of omics technologies, including genomics, proteomics, metabolomics, transcriptomics, lipidomics, cytomics, metallomics, ionomics, interactomics, and phenomics. These omics are often based on global analyses of biological samples using high through-put analytical approaches and bioinformatics and may provide new insights into biological phenomena. In this paper, the development and advances in these omics made in the past decades are reviewed, especially genomics, transcriptomics, proteomics and metabolomics; the applications of omics technologies in pharmaceutical research are then summarized in the fields of drug target discovery, toxicity evaluation, personalized medicine, and traditional Chinese medicine; and finally, the limitations of omics are discussed, along with the future challenges associated with the multi-omics data processing, dynamics omics analysis, and analytical approaches, as well as amenable solutions and future prospects.
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“Omics” in pharmaceutical research:overview, applications, challenges, and future perspectives

    Corresponding author:
  • 1. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China;
  • 2. School of Pharmacy, Second Military Medical University, Shanghai 200433, China;
  • 3. Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China
Fund Project:  The work was supported by Professor of Chang Jiang Scholars Program, NSFC (No. 81230090), Shanghai Leading Academic Discipline Project (B906), Key laboratory of drug research for special environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (No. 10DZ2251300), the Scientific Foundation of Shanghai, China (Nos. 12401900801, 13401900 101), National Major Project of China (No. 2011ZX09307-002-03) and the National Key Technology R&D Program of China (No. 2012BAI29B06)

Abstract: In the post-genomic era, biological studies are characterized by the rapid development and wide application of a series of omics technologies, including genomics, proteomics, metabolomics, transcriptomics, lipidomics, cytomics, metallomics, ionomics, interactomics, and phenomics. These omics are often based on global analyses of biological samples using high through-put analytical approaches and bioinformatics and may provide new insights into biological phenomena. In this paper, the development and advances in these omics made in the past decades are reviewed, especially genomics, transcriptomics, proteomics and metabolomics; the applications of omics technologies in pharmaceutical research are then summarized in the fields of drug target discovery, toxicity evaluation, personalized medicine, and traditional Chinese medicine; and finally, the limitations of omics are discussed, along with the future challenges associated with the multi-omics data processing, dynamics omics analysis, and analytical approaches, as well as amenable solutions and future prospects.

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