Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines

Ravichandran Senthilkumar; CHEN Bao-An; CAI Xiao-Hui; FU Rong

Volume 12 Issue 12

Dec. 2014

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Article Contents

Article Navigation > Chinese Journal of Natural Medicines > 2014 > 12(12): 881-894

Citation:

Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines

1.
Department of Neoplastic Hematologic Disorders(Medical Science Key Subject of Jiangsu Province), Zhongda Hospital, Schoool of Medicine, Southeast University, Nanjing 210009, China;
2.
Department of Oncology, School of Medicine, Southeast University, Nanjing 210009, China;
3.
State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China

Corresponding author:
Received Date: 18-Dec.-2013

Fund Project: This project was supported by the National Natural Science Foundation of P.R.China(Nos.81170492,81370673),National High Technology Research and Development Program 863 of P.R.China(No.2012AA022703),National Key Basic Research Program 973 of P.R.China(No.2010CB732404),Key Medical Projects of Jiangsu Province(No.BL2014078) and Key Discipline of Jiangsu Province(2011-2015).

Abstract

Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases.It occurs in cultured tumor cell lines,as well as in human cancers.Therefore,it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients.Plant-derived natural products have been used for the treatment of various diseases for thousands of years.This review summarizes the anticancer and multidrug-resistance reversing properties of the extracts and bioactive compounds from traditional medicinal plants in different leukemia cell lines.Further mechanistic studies will pave the road to establish the anticancer potential of plant-derived natural compounds.
- Traditional medicinal plants,
- Leukemia,
- Multidrug resistance(MDR),
- Reversal multidrug resistance,
- Apoptosis

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines

Corresponding author:

1. Department of Neoplastic Hematologic Disorders(Medical Science Key Subject of Jiangsu Province), Zhongda Hospital, Schoool of Medicine, Southeast University, Nanjing 210009, China;

2. Department of Oncology, School of Medicine, Southeast University, Nanjing 210009, China;

3. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China

Received Date: 2013-12-18

Fund Project: This project was supported by the National Natural Science Foundation of P.R.China(Nos.81170492,81370673),National High Technology Research and Development Program 863 of P.R.China(No.2012AA022703),National Key Basic Research Program 973 of P.R.China(No.2010CB732404),Key Medical Projects of Jiangsu Province(No.BL2014078) and Key Discipline of Jiangsu Province(2011-2015).

Abstract: Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases.It occurs in cultured tumor cell lines,as well as in human cancers.Therefore,it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients.Plant-derived natural products have been used for the treatment of various diseases for thousands of years.This review summarizes the anticancer and multidrug-resistance reversing properties of the extracts and bioactive compounds from traditional medicinal plants in different leukemia cell lines.Further mechanistic studies will pave the road to establish the anticancer potential of plant-derived natural compounds.

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Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines

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通讯作者: 陈斌, bchen63@163.com

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