Volume 12 Issue 12
Dec.  2014
Turn off MathJax
Article Contents


Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines

  • Corresponding author:
  • Received Date: 18-Dec.-2013
    Fund Project: This project was supported by the National Natural Science Foundation of P.R.China(Nos.81170492,81370673),National High Technology Research and Development Program 863 of P.R.China(No.2012AA022703),National Key Basic Research Program 973 of P.R.China(No.2010CB732404),Key Medical Projects of Jiangsu Province(No.BL2014078) and Key Discipline of Jiangsu Province(2011-2015).
  • Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases.It occurs in cultured tumor cell lines,as well as in human cancers.Therefore,it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients.Plant-derived natural products have been used for the treatment of various diseases for thousands of years.This review summarizes the anticancer and multidrug-resistance reversing properties of the extracts and bioactive compounds from traditional medicinal plants in different leukemia cell lines.Further mechanistic studies will pave the road to establish the anticancer potential of plant-derived natural compounds.
  • 加载中
  • [1]

    Global Status Report on Non-communicable Diseases 2010[M].World Health Organization,Geneva,2011.ISBN:9789241564229.

    Swerdlow SH,Campo E,Harris NL,et al.(eds).WHO classification of tumours of haematopoietic and lymphoid tissues[M].2008,4th ed.IARC Press.

    Pan L,Chai H,Kinghorn AD.The continuing search for antitumor agents from higher plants[J].Phytochem Lett,2010,3(1):1-8.

    DeVita VT,Hellman S,Rosenberg SA.Cancer:Principles and Practice of Oncology[M].8th ed.Lippincott-Williams Wilkins,Philadelphia,2008.

    Gupta SC,Kim JH,Prasad S,et al.Regulation of survival,proliferation,invasion,angiogenesis,and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals[J].Cancer Metastasis Rev,2010,29(3):405-434.

    Lu QY,Arteaga JR,Zhang Q,et al.Inhibition of prostate cancer cell growth by an avocado extract:role of lipid-soluble bioactive substances[J].J Nutr Biochem,2005,16(1):23-30.

    Kelloff GJ,Crowell JA,Steele VE,et al.Progress in cancer chemoprevention[J].Ann NY Acad Sci,1999,889:1-13.

    Surh YJ.Cancer chemoprevention with dietary phytochemicals[J].Nat Rev Cancer,2003,3(10):768-780.

    Reddy L,Odhav B,Bhoola KD.Natural products for cancer prevention:a global perspective[J].Pharmacol Ther,2003,99(1):1-13.

    Levis AG,Danieli GA,Piccinni E.Nucleic acid synthesis and the mitotic cycle in mammalian cells treated with nitrogen mustard in culture[J].Nature,1965,207(997):608-610.

    Rosenberg HM,Gregg EC.Kinetics of cell volume changes of murine lymphoma cells subjected to different agents in vitro[J].Biophys J,1969,9(4):592-606.

    Leslie EM,Deeley RG,Cole SPC.Multidrug resistance proteins:role of P-glycoprotein,MRP1,MRP2 and BCRP(ABCG2) in tissue defense[J].Toxicol Appl Pharmacol,2005,204(3):216-237.

    Girardin F.Membrane transporter proteins:a challenge for CNS drug development[J].Dialog Clin Neurosci,2006,8(3):311-321.

    Szakcs G,Paterson JK,Ludwig JA,et al.Targeting multidrug resistance in cancer[J].Nat Rev Drug Discov,2006,5(3):219-234.

    Nabekura T.Overcoming multidrug resistance in human cancer cells by natural compounds[J].Toxins,2010,2(6):1207-1224.

    Ugocsai K,Varga A,Molnar P,et al.Effects of selected flavonoids and carotenoids on drug accumulation and apoptosis induction in multidrug-resistant colon cancer cells expressing MDR1/LRP[J].In Vivo,2005,19(2):433-438.

    Eichhorn T,Efferth T.P-Glycoprotein and its inhibition in tumors by phytochemicals derived from Chinese herbs[J].J Ethnopharmacol,2012,141(2):557-570.

    Yan XJ,Gong LH,Zheng FY,et al.Triterpenoids as reversal agents for anticancer drug resistance treatment[J].Drug Discov Today,2013,19(4):482-488.

    Xue X,Yu JL,Sun DQ,et al.Curcumin as a multidrug resistance modulator-a quick review[J].Biomed Prev Nutr,2013,3(2):173-176.

    Kumar D,Arya V,Kaur R,et al.A review of immunomodulators in the Indian traditional health care system[J].J Microbiol Immunol Infect,2012,45(3):165-184.

    Xie W,Zhao Y,Du L.Emerging approaches of traditional Chinese medicine formulas for the treatment of hyperlipidemia[J].J Ethnopharmacol,2012,140(2):345-367.

    Willimott S,Barker J,Jones LA,et al.An in vitro based investigation of the cytotoxic effect of water extracts of the Chinese herbal remedy LD on cancer cells[J].Chem Cent J,2009,3(12):1-16.

    Lau CH,Chan CM,Chan YW,et al.In vitro antidiabetic activities of five medicinal herbs used in Chinese medicinal formulae[J].Phytother Res,2008,22(10):1384-1388.

    Lau TW,Chan YW,Lau CP,et al.Investigation of the effects of Chinese medicine on fibroblast viability:implications in wound healing[J].Phytother Res,2007,21(10):938-947.

    Wang C,Zhang JX,Shen XL,et al.Reversal of P-glycoproteinmediated multidrug resistance by alisol B 23-acetate[J].Biochem Pharmacol,2004,68(5):843-855.

    Fong WF,Wang C,Zhu GY,et al.Reversal of multidrug resistance in cancer cells by Rhizoma alismatis extract[J].Phytomedicine,2007,14(2):160-165.

    Lim TK.Edible Medicinal and Non-Medicinal Plants[M].Volume 1,Fruits.2012,Springer Netherlands,ISBN:978-90-481-8660-0(Print) 978-90-481-8661-7(Online).

    Padmaja V,Thankamany V,Hara N,et al.Biological activities of Annona glabra[J].J Ethnopharmacol,1995,48(1):21-24.

    Zhang YH,Pang HY,Xia GH,et al.Anticancer effect of two diterpenoid compounds isolated from Annona glabra Linn[J].Acta Pharmacol Sin,2004,25(7):937-942.

    Cochrane CB,Nair RBK,Melnick SJ,et al.Anticancer effects of Annona glabra plant extracts in human leukemia cell lines[J].Anticancer Res,2008,28(2A):965-972.

    Seidemann J.Chokeberries a fruit little-known till now[J].Dtsch Lebensmitt Rundsch,1993,89:149-51.

    Kulling SE,Rawel HM.Chokeberry(Aronia melanocarpa)-A review on the characteristic components and potential health effects[J].Planta Med,2008,74(13):1625-1634.

    Bermudez-Soto MJ,Tomas-Barberan FA.Evaluation of commercial red fruit juice concentrates as ingredients for antioxidant functional juices[J].Eur Food Res Technol,2004,219(2):133-141.

    Sharif T,Alhosin M,Auger C,et al.Aronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells[J].PLoS One,2012,7(3):1-11,e32526.

    Liu XF,Xia YM,Fang Y.Effect of metal ions on the interaction between bovine serum albumin and berberine chloride extracted from a traditional Chinese herb Coptis chinensis Franch[J].J Inorg Biochem,2005,99(7):1449-1457.

    Ghosh AK,Bhattacharyya FK,Ghosh DK.Leishmania donovani:amastigote inhibition and mode of action of berberine[J].Exp Parasitol,1985,60(3):404-413.

    Yan D,Jin C,Xiao XH,et al.Antimicrobial properties of berberines alkaloids in Coptis chinensis Franch by microcalorimetry[J].J Biochem Biophys Methods,2008,70(6):845-849.

    Li B,Liu HR,Pan YQ,et al.Protective effects of total alkaloids from rhizome Coptis chinensis on alcohol-induced gastric lesion in rats[J].Chin J Chin Mater Med,2006,31(1):51-54.

    Lin CC,Ng LT,Hsu FF,et al.Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents(berberine,coptisine and icariin) on hepatoma and leukaemia cell growth[J].Clin Exp Pharmacol Physiol,2004,31(1-2):65-69.

    Lin CC,Kao ST,Chen GW,et al.Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3[J].Anticancer Res,2006,26(1A):227-242.

    Pharmacopoeia of People's Republic of China,The State Pharmacopoeia Committee of People's Republic of China[M].Vol.1.Beijing(China):Chemical Industry Press,2010.

    Huang YC,Guh JH,Teng CM.Induction of mitotic arrest and apoptosis by evodiamine in human leukemic T-lymphocytes[J].Life Sci,2004,75(1):35-49.

    Lee TJ,Kim EJ,Kim S,et al.Caspase-dependent and caspaseindependent apoptosis induced by evodiamine in human leukemic U937 cells[J].Mol Cancer Ther,2006,5(9):2398-2407.

    Panthong A,Norkaew P,Kanjanapothi D,et al.Antiinflammatory,analgesic and antipyretic activities of the extract of gamboge from Garcinia hanburyi Hook f.[J].J Ethnopharmacol,2007,111(2):335-340.

    Li SL,Song JZ,Han QB,et al.Improved high-performance liquid chromatographic method for simultaneous determination of 12 cytotoxic caged xanthones in gamboges,a potential anticancer resin from Garcinia hanburyi[J].Biomed Chromatogr,2008,22(6):637-644.

    Zhao L,Guo QL,You QD,et al.Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells[J].Biol Pharm Bull,2004,27(7):998-1003.

    Hahnvajanawong C,Boonyanugomol W,Nasomyon T,et al.Apoptotic activity of caged xanthones from Garcinia hanburyi in cholangiocarcinoma cell lines[J].World J Gastroenterol,2010,16(18):2235-2243.

    Han QB,Wang YL,Yang L,et al.Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi[J].Chem Pharm Bull,2006,54(2):265-267.

    Laurens A,Mboup S,Tignokpa M,et al.Antimicrobial activity of some medicinal species from the Dakar markets[J].Pharmazie,1985,40(7):482-484.

    el-Hamidi A.Drug plants of the Sudan Republic in native medicine[J].Planta Med,1970,18(3):279-280.

    Hussain MM,Sokomba EN,Shok M.Pharmacological effects of Gardenia erubescens in mice,rats and cats[J].Pharm Biol,1991,29(2):94-100.

    Smitinand T.Thai Plant Names[M].Revised edition by The Forest Herbarium,Royal Forest Department,Pra Cha Chon Co.,Ltd:Bangkok,2001:248-249.

    Phromnoi K,Reuter S,Sung B,et al.A dihydroxy-pentamethoxy flavone from Gardenia obtusifolia suppresses proliferation and promotes apoptosis of tumor cells through modulation of multiple cell signaling pathways[J].Anticancer Res,2010,30:3599-3610.

    Madhava K,et al.Flowering Plants of Chittoor District[M].Students Offset Printers,Tirupathi,Andhra Pradesh,India.1st ed.2008:198.

    Kumarappan CT,Mandal SC.Antitumor activity of polyphenolic extract of Ichnocarpus frutescens[J].Exp Oncol,2007,29(2):94-101.

    Silva EC,Cavalcanti BC,Amorim RC,et al.Biological activity of neosergeolide and isobrucein B(and two semi-synthetic derivatives) isolated from the Amazonian medicinal plant Picrolemma sprucei(Simaroubaceae)[J].Mem Inst Oswaldo Cruz,2009,104(1):48-56.

    Cavalcanti BC,da Costa PM,Carvalho AA,et al.Involvement of intrinsic mitochondrial pathway in neosergeolide-induced apoptosis of human HL-60 leukemia cells:the role of mitochondrial permeability transition pore and DNA damage[J].Pharm Biol,2012,50(8):980-993.

    Steiner GG.The correlation between cancer incidence and kava consumption[J].Hawaii Med J,2000,59(11):420-422.

    Lehmann E,Kinzler E,Friedemann J.Efficacy of a special kava extract(Piper methysticum) in patients with states of anxiety,tension and excitedness of non-mental origin-A double-blind placebo-controlled study of four weeks treatment[J].Phytomedicine,1996,3(2):113-119.

    Teschke R,Schulze J.Risk of kava hepatotoxicity and the FDA consumer advisory[J].JAMA,2010,304(19):2174-2175.

    Warmka JK,Solberg EL,Zeliadt NA,et al.Inhibition of mitogen activated protein kinases increases the sensitivity of A549 lung cancer cells to the cytotoxicity induced by a kava chalcone analog[J].Biochem Biophys Res Commun,2012,424(3):488-492.

    Li X,Liu Z,Xu X,et al.Kava components down-regulate expression of AR and AR splice variants and reduce growth in patient-derived prostate cancer xenografts in mice[J].PLoS One,2012,7(2):e31213.

    Kuo YF,Su YZ,Tseng YH,et al.Flavokawain B,a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity:Involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells[J].Free Radic Biol Med,2010,49(2):214-226.

    Lin E,Lin WH,Wang SY,et al.Flavokawain B inhibits growth of human squamous carcinoma cells:Involvement of apoptosis and cell cycle dysregulation in vitro and in vivo[J].J Nutr Biochem,2012,23(4):368-378.

    Sakai T,Eskander RN,Guo Y,et al.Flavokawain B,a kava chalcone,induces apoptosis in synovial sarcoma cell lines[J].J Orthop Res,2012,30(7):1045-1050.

    Eskander RN,Randall LM,Sakai T,et al.Flavokawain B,a novel,naturally occurring chalcone,exhibits robust apoptotic effects and induces G2/M arrest of a uterine leiomyosarcoma cell line[J].J Obstet Gynaecol Res,2012,38(8):1086-1094.

    Ji T,Lin C,Krill LS,et al.Flavokawain B,a kava chalcone,inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis[J].Molecular Cancer,2013,12(55):1-11.

    Weiss J,Sauer A,Frank A,et al.Extracts and kavalactones of Piper methysticum G.Forst(Kava-Kava) inhibit P-glycoprotein in vitro[J].Drug Metab Dispos,2005,33(11):1580-1583.

    Narayanan N,Thirugnanasambantham P,Viswanathan S,et al.Antipyretic,antinociceptive and anti-inflammatory activity of Premna herbacea roots[J].Fitoterapia,2000,71(2):147-153.

    Nayar R,Yoganarsimhan S,Subramanyam K.Pharmacognosy of a local market sample of bharangin:pygmacopremna herbaceae[J].Ind J Pharmacol,1976,38:39-44.

    Gupta SC,Kannappan R,Kim J,et al.Bharangin,a diterpenoid quinonemethide,abolishes constitutive and inducible nuclear factor-B(NF-B) activation by modifying p65 on cysteine 38 residue and reducing inhibitor of nuclear factor-B kinase activation,leading to suppression of NF-B-regulated gene expression and sensitization of tumor cells to chemotherapeutic agents[J].Mol Pharmacol,2011,80(5):769-781.

    Liu R,Li A,Sun A,et al.Preparative isolation and purification of psoralen and isopsoralen from Psoralea corylifolia by high-speed counter-current chromatography[J].J Chromatogr A,2004,1057(1-2):225-228.

    Wang Y,Hong C,Zhou C,et al.Screening antitumor compounds psoralen and isopsoralen from Psoralea corylifolia L.seeds[J].Evid Based Complement Alternat Med,2011,2011:1-7.

    Jin Z.Amaryllidaceae and Sceletium alkaloids[J].Nat Prod Rep,2013,30(6):849-868.

    Zupko I,Rethy B,Hohmann J,et al.Antitumor activity of alkaloids derived from Amaryllidaceae species[J].In Vivo,2009,23(1):41-48.

    Skupien K,Oszmianski J,Kostrzewa-Nowak D,et al.In vitro antileukaemic activity of extracts from berry plant leaves against sensitive and multidrug resistant HL60 cells[J].Cancer Lett,2006,236(2):282-291.

    Kuete V,Krusche B,Youns M,et al.Cytotoxicity of some Cameroonian spices and selected medicinal plant extracts[J].J Ethnopharmacol,2011,134(3):803-812.

    Gupta A,Kumar R,Upadhyay NK,et al.Effects of Rhodiola imbricata on dermal wound healing[J].Planta Med,2007,73(8):774-7.

    Kurkin GG.Zapiesocznaja,Chemiczeskij sostaw i farmakologiczeskije swojstwa rastienij roda Rodiola[J].Khim.-Farmacievticheskiy Zh,1986,20:1231-1244.

    Khanum F,Bawa AS,Singh B.Rhodiola rosea:a versatile adaptogen[J].Compr Rev Food Sci Food,2005,4(3):55-62.

    Mishra KP,Padwad YS,Dutta A,et al.Aqueous extract of Rhodiola imbricata rhizome inhibits proliferation of an erythroleukemic cell line K-562 by inducing apoptosis and cell cycle arrest at G2/M phase[J].Immunobiology,2008,213(2):125-131.

    Kelly GS,Rhodiola rosea:a possible plant adaptogen[J].Altern Med Rev,2001,6(3):293-302.

    Majewska A,Grazyna H,Mirosława F,et al.Antiproliferative and antimitotic effect,S phase accumulation and induction of apoptosis and necrosis after treatment of extract from Rhodiola rosea rhizomes on HL-60 cells[J].J Ethnopharmacol,2006,103(1):43-52.

    Efferth T,Davey M,Olbrich A,et al.Activity of drugs from traditional Chinese medicine toward sensitive and MDR1-or MRP1-overexpressing multidrug resistant human CCRF-CEM leukemia cells[J].Blood Cells Mol Dis,2002,28(2):160-168.

    Ritch-Krc EM,Thomas S,Turner NJ,et al.Carrier herbal medicine:traditional and contemporary plant use[J].J Ethnopharmacol,1996,52(2):85-94.

    Deeg K,Eichhorn T,Alexie G,et al.Growth inhibition of human acute lymphoblastic CCRF-CEM leukemia cells by medicinal plants of the West-Canadian Gwich'in Native Americans[J].Nat Prod Bioprospect,2012,2(1):35-40.

    Efferth T,Sauerbrey A,Olbrich A,et al.Molecular modes of action of artesunate in tumor cell lines[J].Mol Pharmacol,2003,64(2):382-394.

    Gillet JP,Efferth T,Steinbach D,et al.Microarray-based detection of multidrug resistance in human tumor cells by expression profiling of ATP-binding cassette transporter genes[J].Cancer Res,2004,64(24):8987-8993.

    Eid SY,El-Readi MZ,Wink M.Synergism of three-drug combinations of sanguinarine and other plant secondary metabolites with digitonin and doxorubicin in multi-drug resistant cancer cells[J].Phytomedicine,2012,19(14):1288-1297.

    El-Readi MZ,Eid SY,Ashour ML,et al.Modulation of multidrug resistance in cancer cells by chelidonine and Chelidonium majus alkaloids[J].Phytomedicine,2013,20(3-4):282-294.

    Wang SQ,Li X,Wang XN,et al.Coumarins from Cicuta virosa and their modulating effects on multidrug-resistant(MDR) tumors[J].Phytochem.Lett,2011,4(2):97-100.

    Iwasaki H,Oku H,Takara,et al.The tumor specific cytotoxicity of dihydronitidine from Toddalia asiatica Lam[J].Cancer Chemother Pharmacol,2006,58(4):451-459.

    Iwasaki H,Okabe T,Takara K,et al.Tumor selective cytotoxicity of benzo[c]phenanthridine derivatives from Toddalia asiatica Lam[J].Cancer Chemother Pharmacol,2010,65(4):719-726.

    Vzquez R,Riveiro ME,Vermeulen M,et al.Toddaculin,a natural coumarin from Toddalia asiatica,induces differenttiationand apoptosis in U-937 leukemic cells[J].Phytomedicine,2012,19(8-9):737-746.

    Shishodia S,Chaturvedi MM,Aggarwal BB.Role of curcumin in cancer therapy[J].Curr Probl Cancer,2007,31(4):243-305.

    Choi BH,Kim CG,Lim Y,et al.Curcumin downregulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF-kappa B pathway[J].Cancer Lett,2008,259(1):111-118.

    Yang CS,Chhabra SK,Hong JY,et al.Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide(DAS) and related compounds from garlic[J].J Nutr,2001,131(3s):1041S-1045S.

    Buiatti E,Palli D,Decarli A,et al.A case-control study of gastric cancer and diet in Italy[J].Int J Cancer,1989,44(4):611-616.

    You WC,Blot W J,Chang Y S,et al.Allium vegetables and reduced risk of stomach cancer[J].J Natl Cancer Inst,1989,81(2):162-164.

    Xia Q,Wang ZY,Li HQ,et al.Reversion of P-glycoproteinmediated multidrug resistance in human leukemic cell line by diallyltrisulfide[J].Evid Based Complement Alternat Med,2012,2012:1-11.

    Li X,Sun B,Zhu CJ,et al.Reversal of P-glycoproteinmediated multidrug resistance by macrocyclic bisbibenzyl derivatives in adriamycin-resistant human myelogenous leukemia(K562/A02) cells[J].Toxicol In Vitro,2009,23(1):29-36.

    Singh RB,Niaz MA,Ghosh S.Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia[J].Cardiovasc Drugs Ther,1994,8(4):659-664.

    Sinal CJ,Gonzalez FJ.Guggulsterone:an old approach to a new problem[J].Trends Endocrinol Metab,2002,13(7):275-276.

    Xu HB,Li L,Liu GQ.Reversal of P-glycoprotein-mediated multidrug resistance by guggulsterone in doxorubicin resistant human myelogenous leukemia(K562/DOX) cells[J].Pharmazie,2009,64(10):660-665.

    Xu HB,Xu LZ,Li L,et al.Reversion of P-glycoproteinmediated multidrug resistance by guggulsterone in multidrugresistant human cancer cell lines[J].EurJ Pharmacol,2012,694(1-3):39-44.

    Hostanska K,Bommer S,Weber M,et al.Comparison of the growth-inhibitory effect of Hypericum perforatum L.extracts,differing in the concentration of phloroglucinols and flavonoids,on leukaemia cells[J].J Pharm Pharmacol,2003,55(7):973-980.

    Quiney C,Billard C,Faussat AM,et al.Pro-apoptotic properties of hyperforin in leukemic cells from patients with B-cellchronic lymphocytic leukemia[J].Leukemia,2006,20(3):491-497.

    Liu JY,Liu Z,Wang DM,et al.Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway[J].Chem Biol Interact,2011,190(2-3):91-101.

    Zaher M,Tang R,Bombarda I,et al.Hyperforin induces apoptosis of chronic lymphocytic leukemia cells through upregulation of the BH3-only protein Noxa[J].Int J Oncol,2012,40(1):269-276.

    Merhi F,Tang R,Piedfer M,et al.Hyperforin inhibits Akt1 kinase activity and promotes caspase-mediated apoptosis involving Bad and Noxa activation in human myeloid tumor cells[J].PLoS One,2011,6(10):1-12.

    Bignon J,Benechie M,Herlem D,et al.A novel iodomethylene-dimethyl-dihydropyranone induces G2/M arrest and apoptosis in human cancer cells[J].Anticancer Res,2009,29(6):1963-1970.

    Traka M,Mithen R.Glucosinolates,isothiocyanates and human health[J].Phytochem Rev,2009,8(1):269-282.

    Jakubikova J,Bao Y,Sedlak J.Isothiocyanates induce cell cycle arrest,apoptosis and mitochondrial potential depolarization in HL-60 and multidrug-resistant cell lines[J].Anticancer Res,2005,25(5):3375-3386.

    Fennell CW,Staden JV.Crinum species in traditional and modern medicine[J].J Ethnopharmacol,2001,78(1):15-26.

    Liu J,Hu WX,He LF,et al.Effects of lycorine on HL-60 cells via arresting cell cycle and inducing apoptosis[J].FEBS Lett,2004,578(3):245-250.

    Liu XS,Jiang J,Jiao XY,et al.Lycorine induces apoptosis and down-regulation of Mcl-1 in human leukemia cells[J].Cancer Lett,2009,274(1):16-24.

    Liu J,Hu JL,Shi BW,et al.Up-regulation of p21 and TNF- is mediated in lycorine-induced death of HL-60 cells[J].Cancer Cell Intl,2010,10(25):1-9.

    Li L,Dai HJ,Ye M,et al.Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition[J].Cancer Cell Int,2012,12(49):1-6.

    Petiwala SM,Puthenveetil AG,Johnson JJ.Polyphenols from the Mediterranean herb rosemary(Rosmarinus officinalis) for prostate cancer[J].Front Pharmacol,2013,4(29):1-4.

    Valdes A,Simo C,Ibanez C,et al.Effect of dietary polyphenols on K562 leukemia cells:A foodomics approach[J].Electrophoresis,2012,33(15):2314-2327.

    Ambudkar SV,Sauna ZE,Gottesman MM,et al.A novel way to spread drug resistance in tumor cells:functional intercellular transfer of P-glycoprotein(ABCB1)[J].Trends Pharmacol Sci,2005,26(8):385-387.

    Yu XN,Chen XL,Li H,et al.Reversion of P-glycoproteinmediated multidrug resistance in human leukemic cell line by carnosic acid[J].Chin J Physiol,2008,51(6):348-356.

    Nijveldt RJ,van Nood E,van Hoorn DE,et al.Flavonoids:a review of probable mechanisms of action and potential applications[J].Am J Clin Nutr,2001,74(4):418-425.

    Niu G,Yin S,Xie S,Li Y,et al.Quercetin induces apoptosis by activating caspase-3 and regulating Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells[J].Acta Biochim Biophys Sin,2011,43(1):30-37.

    Chen X,Yang L,Oppenheim JJ,et al.Cellular pharmacology studies of shikonin derivatives[J].Phytother Res,2002,16(3):199-209.

    Sankawa U,Ebizuka Y,Miyazaki T,et al.Antitumor activity of shikonin and its derivatives[J].Chem Pharm Bull,1977,25(9):2392-2395.

    Wiench B,Eichhorn T,Paulsen M,et al.Shikonin directly targets mitochondria and causes mitochondrial dysfunction in cancer cells[J].Evid Based Complement Alternat Med,2012,2012:1-15.

    Lee YS,Han SH,Lee SH,et al.The mechanism of antibacterial activity of tetrandrine against Staphylococcus aureus[J].Foodborne Pathog Dis,2012,9(8):686-691.

    Fu L,Liang Y,Deng L,et al.Characterization of tetrandrine,a potent inhibitor of P-glycoprotein-mediated multidrug resistance[J].Cancer Chemother Pharmacol,2004,53(4):349-356.

    Shen H,Xu W,Chen Q,et al.Tetrandrine prevents acquired drug resistance of K562 cells through inhibition of mdr1 gene transcription[J].J Cancer Res Clin Oncol,2010,136(5):659-665.

    Chen B,Sun Q,Wang X,et al.Reversal in multidrug resistance by magnetic nanoparticle of Fe3O4 loaded with adriamycin and tetrandrine in K562/A02 leukemic cells[J].Int J Nanomedicine,2008,3(2):277-286.

    Xu WL,Shen HL,Ao ZF,et al.Combination of tetrandrine as a potential-reversing agent with daunorubicin,etoposide and cytarabine for the treatment of refractory and relapsed acute myelogenous leukemia[J].Leuk Res,2006,30(4):407-413.

    Liby KT,Yore MM,Sporn MB.Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer[J].Nat Rev Cancer,2007,7(5):357-369.

    Fernandesa J,Castilhob RO,da Costaa MR,et al.Pentacyclic triterpenes from Chrysobalanaceae species:cytotoxicity on multidrug resistant and sensitive leukemia cell lines[J].Cancer Lett,2003,190(2):165-169.

    Shishodia S,Sethi G,Konopleva M,et al.A synthetic triterpenoid,CDDO-Me,inhibits I□B kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor □B-regulated gene products in human leukemic cells[J].Clin Cancer Res,2006,12(6):1828-1838.

    Rocha GG,Simoes M,Lucio KA,et al.Natural triterpenoids from Cecropia lyratiloba are cytotoxic to both sensitive and multidrug resistant leukemia cell lines[J].Bioorg Med Chem,2007,15(23):7355-7360.

    Ikegawa T,Ushigome F,Koyabu N,et al.Inhibition of P-glycoprotein by orange juice components,polymethoxyflavones in adriamycin-resistant human myelogenous leukemia(K562/ADM) cells[J].Cancer Lett,2000,160(1):21-28.

    Puissant A,Grosso S,Jacquel A,et al.Imatinib mesylate-resistant human chronic myelogenous leukemia cell lines exhibit high sensitivity to the phytoalexin resveratrol[J].FASEB J,2008,22(6):1894-1904.

    Mohan R,Hammers HJ,Bargagna-Mohan P,et al.Withaferin A is a potent inhibitor of angiogenesis[J].Angiogenesis,2004,7(2):115-122.

    Suttana W,Mankhetkorn S,Poompimon W,et al.Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols[J].Mol Cancer,2010,9(99):1-22.

    Liao K,Niu F,Hao HP,et al.Advances on structure-activity relationship of NQO1-target antitumor quinones[J].Chin J Nat Med,2012,10(3):170-176

    Loscher W,Potschka H.Blood-brain barrier active efflux transporters:ATP-binding cassette gene family[J].Neurotherapeutics,2005,2(1):86-98.

    Palmeira A,Sousa E,Vasconcelos MH,et al.Three decades of P-gp inhibitors:skimming through several generations and scaffolds[J].Curr Med Chem,2012,19(13):1946-2025.

    Wu CP,Ohnuma S,Ambudkar SV.Discovering natural product modulators to overcome multidrug resistance in cancer chemotherapy[J].Curr Pharm Biotechnol,2011,12(4):609-620.

    PENG MX,ZHANG HW,CHEN BA.Main signal pathways underlying the molecular mechanisms of the antitumor effects of wogonin[J].Chin J Nat Med,2012,10(6):401-407.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(7247) PDF downloads(951) Cited by()

Proportional views

Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines

    Corresponding author:
  • 1. Department of Neoplastic Hematologic Disorders(Medical Science Key Subject of Jiangsu Province), Zhongda Hospital, Schoool of Medicine, Southeast University, Nanjing 210009, China;
  • 2. Department of Oncology, School of Medicine, Southeast University, Nanjing 210009, China;
  • 3. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China
Fund Project:  This project was supported by the National Natural Science Foundation of P.R.China(Nos.81170492,81370673),National High Technology Research and Development Program 863 of P.R.China(No.2012AA022703),National Key Basic Research Program 973 of P.R.China(No.2010CB732404),Key Medical Projects of Jiangsu Province(No.BL2014078) and Key Discipline of Jiangsu Province(2011-2015).

Abstract: Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases.It occurs in cultured tumor cell lines,as well as in human cancers.Therefore,it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients.Plant-derived natural products have been used for the treatment of various diseases for thousands of years.This review summarizes the anticancer and multidrug-resistance reversing properties of the extracts and bioactive compounds from traditional medicinal plants in different leukemia cell lines.Further mechanistic studies will pave the road to establish the anticancer potential of plant-derived natural compounds.

Reference (145)



    DownLoad:  Full-Size Img  PowerPoint