Volume 10 Issue 1
Feb.  2012
Turn off MathJax
Article Contents

Citation:

Chemical constituents of Spatholobus suberectus

  • Received Date: 05-Jan.-2011
    Fund Project: This project was supported by the grants from National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China (Nos. 2009ZX09308-005, 2009ZX09311-001, 2009ZX09502-020, 2009ZX09304-002), and Major Projects of Knowledge Innovation Program of the Chinese Academy of Sciences (No. KSCX2-YW-R-166).
  • AIM: To investigate chemical constituents of Spatholobus suberectus Dunn. METHODS: Isolation and purification were carried out by column chromatographic methods. Compounds were characterized based on their physical characteristics and spectra data. RESULTS: Seventeen compounds were isolated from ethanol extract of S. suberectus. The structures were elucidated as prestegane B (1), (2R, 3R)-buteaspermanol (2), (+)-medioresinol (3), (2R, 3R)-3,7-dihydroxyflavanone (4), benzeneethanol (5), 4, 7, 2'-trihydroxy-4'-methoxyisoflavanol (6), naringenin (7), blumenol A (8), protocatechuic acid ethyl ester (9), liquiritigenin (10), 7, 4'-dihydroxy-8-methoxy-isoflavone (11), 3, 5, 7, 3', 5'-pentahydroxyflavanone (12), protocatechuic acid (13), glycyroside (14), 8-methylretusin-7-O--D-glucopyranoside (15), 3, 3', 4', 5, 6, 7, 8-heptahydroxyflavan (16), and dulcisflavan (17). CONCLUSION: All compounds are firstly isolated from the title plant and compounds 1, 3 were isolated from the Spatholobus genus for the first time.
  • 加载中
  • [1]

    Nanjing University of Chinese Medicine. Zhong Yao Da Ci Dian[M]. (second edn.) Shanghai:Science and Technology Press, 2006:1688-1690.
    [2]

    Wink M, Mohamed G. Evolution of chemical defense traits in the Leguminosae:mapping of distribution patterns of secondary metabolites on a molecular phylogeny inferred from nucleotide sequences of the rbcL gene[J]. Biochem Syst Ecol, 2003, 31(8):897-917.
    [3]

    Lee MH, Lin YP, Hsu FL, et al. Bioactive constituents of Spatholobus suberectus in regulating tyrosinase-related proteins and mRNA in HEMn cells[J]. Phytochemistry, 2006, 67(12):1262-1270.
    [4]

    Meragelman KM, McKee TC, Boyd MR. 10-Demethoxystegane, a new lignan from Steganotaenia araliacea[J]. J Nat Prod, 2001, 64(11):1480-1482.
    [5]

    Maurya R, Yadav DK, Singh G, et al. Osteogenic activity of constituents from Butea monosperma[J]. Bioorg Med Chem Lett, 2009, 19(3):610-613.
    [6]

    Yuan XH, Xu CX, Zhou M, et al. Chemical constituents of Daphne tangutica[J]. Nat Prod Res Dev, 2007, 19(1):55-58.
    [7]

    Park YH, Moon BH, Lee EJ, et al. 1H and 13C NMR data of hydroxyflavone derivatives[J]. Magn Reson Chem, 2007, 45(8):674-679.
    [8]

    Comar JM, Phale OJK, Abegaz BM, et al. Phloroglucinol derivatives and flavones from Helichrysum paronychioides[J]. Bull Chem Soc Ethiop, 2006, 20(1):61-68.
    [9]

    Gomotsang B, Cornelius CWW, Runner RTM, et al. Two new isoflavanoids from Bolusanthus speciosus[J]. Bull Chem Soc Ethiopia, 2001, 15(2):131-136.
    [10]

    Dong CX, Wu KS, Shi SP, et al. Flavanoids from Clematis hexapetala[J]. J Chin Pharm Sci, 2006, 15(1):15-20.
    [11]

    Xie GB, Zhao MB, Wang XJ, et al. Chemical constituents of Ilex pernyi[J]. Chin Tradit Herb Drugs, 2008, 39(8):1132-1135.
    [12]

    Zhao YY, Cui CB, Cai B, et al. Chemical constituents from Bauhinia variegata L.[J]. Chin J Med Chem, 2005, 15(5):302-304.
    [13]

    Shi HM, Huang ZQ, Wen J, et al. A new isoflavone from Abrus mollis[J]. Chin J Nat Med, 2006, 4(1):30-31.
    [14]

    Yi JH, Zhang GL, Li BG. Studies on the chemical constituents of Pseudotsuga sinensis[J]. Acta Pharm Sin, 2002, 37(5):352-354.
    [15]

    Wang XS, Che QM, Li YM, et al. A study on chemical constituents in seeds of Crataegus pinnatifida Bge. var major N.E.Br.[J]. China J Chin Mater Med, 1999, 24(12):739-740.
    [16]

    Liu Q, Liu YL. Chemical constituents of Glycyrrhiza eurycarpa P.C.Li[J]. Acta Pharm Sin, 1989, 24(7):525-531.
    [17]

    Ma WG, Fukushi Y, Ducrey B, et al. Phenolic glycosides from Eriosema tuberosum[J]. Phytochemistry, 1999, 51(8):1087-1093.
    [18]

    Lu WJ, Chen JY, Wei H, et al. Isoflavones from Abrus mollis[J]. Chin Tradit Herb Drugs, 2004, 35(12):1331-1333.
    [19]

    Moyo F, Gashe BA, Majinda RRT. A new flavan from Elephantorrhiza goetzei[J]. Fitoterapia, 1999, 70(4):412-416.
    [20]

    Deachathai S, Mahabusarakam W, Phongpaichit S, et al. Phenolic compounds from the fruit of Garcinia dulcis[J]. Phytochemistry, 2005, 66(19):2368-2375.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(13145) PDF downloads(308) Cited by()

Related
Proportional views

Chemical constituents of Spatholobus suberectus

  • 1. Changchun University of Chinese Medicine, Changchun 130117, China;
  • 2. Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Fund Project:  This project was supported by the grants from National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China (Nos. 2009ZX09308-005, 2009ZX09311-001, 2009ZX09502-020, 2009ZX09304-002), and Major Projects of Knowledge Innovation Program of the Chinese Academy of Sciences (No. KSCX2-YW-R-166).

Abstract: AIM: To investigate chemical constituents of Spatholobus suberectus Dunn. METHODS: Isolation and purification were carried out by column chromatographic methods. Compounds were characterized based on their physical characteristics and spectra data. RESULTS: Seventeen compounds were isolated from ethanol extract of S. suberectus. The structures were elucidated as prestegane B (1), (2R, 3R)-buteaspermanol (2), (+)-medioresinol (3), (2R, 3R)-3,7-dihydroxyflavanone (4), benzeneethanol (5), 4, 7, 2'-trihydroxy-4'-methoxyisoflavanol (6), naringenin (7), blumenol A (8), protocatechuic acid ethyl ester (9), liquiritigenin (10), 7, 4'-dihydroxy-8-methoxy-isoflavone (11), 3, 5, 7, 3', 5'-pentahydroxyflavanone (12), protocatechuic acid (13), glycyroside (14), 8-methylretusin-7-O--D-glucopyranoside (15), 3, 3', 4', 5, 6, 7, 8-heptahydroxyflavan (16), and dulcisflavan (17). CONCLUSION: All compounds are firstly isolated from the title plant and compounds 1, 3 were isolated from the Spatholobus genus for the first time.

Reference (20)

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return