VU Van-Tuan, XU Xiao-Juan, CHEN Kang, NGUYEN Manh-Tuyen, NGUYEN Bich-Ngoc, PHAM Giang-Nam, KONG Ling-Yi, LUO Jian-Guang. New oligomeric neolignans from the leaves of Magnolia officinalis var. biloba [J].Chin J Nat Med, 2021, 19(7): 491-499. DOI: 10.1016/S1875-5364(21)60048-1
Citation: VU Van-Tuan, XU Xiao-Juan, CHEN Kang, NGUYEN Manh-Tuyen, NGUYEN Bich-Ngoc, PHAM Giang-Nam, KONG Ling-Yi, LUO Jian-Guang. New oligomeric neolignans from the leaves of Magnolia officinalis var. biloba [J].Chin J Nat Med, 2021, 19(7): 491-499. DOI: 10.1016/S1875-5364(21)60048-1

New oligomeric neolignans from the leaves of Magnolia officinalis var. biloba

  • Six new oligomeric neolignans including two trimeric neolignans ( 1 and 2 ) and four dimeric neolignans ( 36 ) were isolated from the leaves of Magnolia officinalis var. biloba. Their structures were determined based on HR-ESIMS and NMR data, as well as electronic circular dichroism (ECD) calculations. Compound 1 is formed from two obovatol moieties directly linked to an aromatic ring of the remaining obovatol moiety, which is an unprecedented type of linkage between monomers. All isolates were assessed for their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophage cells. Compounds 1 and 3 showed significantly inhibitory activities with IC50 values of 6.04 and 3.26 μmol·L−1, respectively.
  • loading

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return