HOU Ji-Qin, ZHAO Heng, YU Jiang-Hong, CHEN Ling-Jun, WANG Hao. New meroterpenoids and C-methylated flavonoid isolated from Baeckea frutescens [J]. Chin J Nat Med, 2020, 18(5): 379-384. doi: 10.1016/S1875-5364(20)30044-3
Citation: HOU Ji-Qin, ZHAO Heng, YU Jiang-Hong, CHEN Ling-Jun, WANG Hao. New meroterpenoids and C-methylated flavonoid isolated from Baeckea frutescens [J]. Chin J Nat Med, 2020, 18(5): 379-384. doi: 10.1016/S1875-5364(20)30044-3
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New meroterpenoids and C-methylated flavonoid isolated from Baeckea frutescens

    Abstract
  • Phytochemical investigation of the aerial parts of Baeckea frutescens resulted in the isolation of three new mono- or sesquiterpene-based meroterpenoids, frutescones S−U ( 1 − 3 ), and one pair of new (±)-5,7-dihydroxy-8-isobutyryl-6-methyldihydroflavonol ( 4 ). Their structures and absolute configurations were established by HR-ESI-MS, 1D and 2D NMR, and quantum chemical ECD calculation. Compound 1 exhibited inhibitory effect on NO production in LPS-activated RAW 264.7 macrophages with an IC50 value being 0.81 µmol·L–1.
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