红花石蒜中的一个新石蒜生物碱
A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata
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摘要: 目的:研究红花石蒜中的石蒜生物碱。方法:采用多种层析柱分离手段,运用NMR和HR-ESI-MS等波谱技术鉴定化合物的结构。此外,生物碱1-10进行了流感甲型病毒的活性测试。结果:从红花石蒜中分离鉴定了1个新石蒜生物碱和9个已知的石蒜生物碱:2-methoxy-6-O-ethyloduline(1),2-methoxy-6-O-methyloduline(2),trispherine(3),8-O-demethylhomolycorine(4),homolycorine(5),9-O-demethylhomolycorine(6),oduline(7),lycorenine(8),6-O-methyllycorenine(9)和O-ethyllycorenine(10)。结论:化合物1为新的高石蒜碱类型的石蒜生物碱,生物碱1-3为该植物中的主要成分,且对流感甲型病毒显示了较弱的抗病毒活性,IC50分别为2.06,0.69,2.71 gmL-1,CC50分别为14.37,4.79,80.12 gmL-1。Abstract: AIM:To study the Amaryllidaceae alkaloids of the bulbs of Lycoris radiata.METHODS:The chemical constituents were isolated and purified by various chromatographic techniques,and the chemical structures were elucidated on the basis of spectroscopic methods.In addition,the antiviral activities of alkaloids 1-10 were evaluated using flu virus A.RESULTS:One new homolycorine-type alkaloid 2-methoxy-6-O-ethyloduline(1),together with nine known alkaloids 2-methoxy-6-O-methyloduline(2),trispherine(3),8-O-demethylhomolycorine(4),homolycorine(5),9-O-demethylhomolycorine(6),oduline(7),lycorenine(8),6-O-methyllycorenine(9) and O-ethyllycorenine(10) were obtained.CONCLUSION:Alkaloid 1 is a new compound,and 1-3 were major alkaloids in this plant.Alkaloids 1-3 showed weak antiviral activities against flu virus A with IC50 values of 2.06,0.69,and 2.71 gmL-1 and CC50 values of 14.37,4.79,and 80.12 gmL-1,respectively.
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