络石藤地上部分中的一个新异黄酮苷

A new isoflavonoid glycoside from the aerial parts of Trachelospermum jasminoides

摘要: 目的:对络石藤地上部分化学成分进行研究。方法:运用多种色谱方法分离化合物,并采用现代光谱技术鉴定化合物的结构。此外,测定了化合物1对HepG2和HL-60的细胞毒活性。结果:从络石藤地上部分分离得到5个苷类化合物:3',7-二甲氧基异黄酮-4',5-二-O-β-D-吡喃葡萄糖苷(1),络石苷(2),去甲络石苷元5'-C-β-D-葡萄糖苷(3),木犀草素-4'-O-β-D-芸香糖苷(4),木犀草素-7-O-β-D-吡喃葡萄糖苷(5)。结论:化合物1为新化合物,对HepG2和HL-60的细胞毒活性显示其IC50为131.5和58.2 μmol·L-1。

Abstract: AIM:To study the chemical constituents from the aerial parts of Trachelospermum jasminoides.METHODS:Compounds were isolated by various chromatographic methods and their structures were elucidated on the basis of spectral techniques.In addition,the inhibitory activity against HepG2 and HL-60 of compound 1 was evaluated.RESULTS:Five compounds were isolated and identified as 3',7-dimethoxyisoflavanone-4',5-di-O-β-D-glucopyranoside(1),tracheloside(2),nortrachelogenin 5'-C-β-glucopyranoside(3),luteolin-4'-O-β-D-rutinoside(4),and luteolin-7-O-β-D-glucopyranoside(5).CONCLUSION:Compound 1 is a new isoflavonoid glycoside.It showed weak inhibitory activity against HepG2 and HL-60 cancer cells with IC50 values of 131.5 and 58.2 μmol·L-1,respectively.