博落回中两个新苯并菲啶类异喹啉生物碱
Two new benzo phenanthridine isoquinoline alkaloids from Macleaya cordata
-
摘要: 目的:对中药博落回的化学成分进行研究。方法:依次采用阳离子交换树脂、硅胶、Sephadex LH-20柱色谱法和重结晶等分离技术,对博落回的生物碱进行分离。并运用多种光谱技术对所得生物碱的结构进行鉴定。结果:从博落回中分离并鉴定了6个苯并菲啶类异喹啉生物碱:6-iso-butanonyldihydrosanguinarine (1), 6-iso-butanonyldihydrochelerythrine (2), 6-丙酮基二氢血根碱(6-acetonyldihydrosanguinarine, 3), 6-丙酮基二氢白屈菜红碱(6-acetonyl-dihydrochelerythrine, 4),二氢血根碱(dihydrosanguinarine, 5)、二氢白屈菜红碱(dihydrochelerythrine, 6)。结论:苯并菲啶类异喹啉生物碱是中药博落回的典型化学成分。化合物1和2为新化合物。Abstract: AIM: To study the chemical constituents of Macleaya cordata (Willd.) R. Br. METHODS: Crude alkaloids were isolated and purified from the fruits with column chromatography of cation exchange, silica gel ad Sephadex LH-20 followed by recrystallization. The structure elucidation was carried out by extensive spectroscopic methods. RESULTS: Two new benzophenanthridine isoquinoline alkaloids, 6-iso-butanonyldihydrosanguinarine (1) and 6-iso-butanonyldihydrochelerythrine (2), along with other four known alkaloid compounds, 6-acetonyldihydrosanguinarine (3), 6-acetonyldihydrochelerythrine (4), dihydrosanguinarine (5) and dihydrochelerythrine (6) have been isolated from fruits of M. cordata collected in Anhui Province of China. CONCLUSION: Benzophenanthridine isoquinoline alkaloids are featured in M. cordata. Compounds 1 and 2 are new ones.
下载: