Hericenone L,猴头菌子实体中的一个新芳香类化合物

Hericenone L, a new aromatic compound from the fruiting bodies of Hericium erinaceums

摘要: 目的:对猴头菌子实体中化学成分进行研究。方法:利用硅胶色谱和高压液相色谱分离技术对猴头菌子实体提取物进行分离纯化,并应用波谱方法鉴定其结构。结果:分离鉴定了3个芳香类化合物,分别为hericenone L (1), hericenone C (2)和hericene A (3)。结论:化合物1是一个新的hericenone型衍生物,经MTT抗肿瘤活性试验发现具有较强的抑制EC109细胞株的活性。

Abstract: AIM: To study the chemical constituents of Hericium erinaceums (Hericiaceae). METHODS: The chemical constituents were isolated using silica gel column chromatography and preparative HPLC, and their structures were elucidated on their basis of the spectral data. RESULTS: Three aromatic compounds were isolated from the fruiting bodies of H. erinaceum and identified as hericenone L (1), hericenone C (2), and hericene A (3). CONCLUSION: Compound 1 is a new derivative of hericenone, and it shows cytotoxic activity against the EC109 cell line by the MTT assay.