产自耐盐真菌<i>Alternaria</i> sp. M6的一个新苝醌类化合物

产自耐盐真菌Alternaria sp. M6的一个新苝醌类化合物

摘要: 目的:研究耐盐真菌Alternaria sp. M6的代谢产物。方法:运用多种色谱分离手段对耐盐真菌Alternaria sp. M6的发酵液及菌丝体部分进行分离纯化。并借助各种波谱学方法鉴定结构。结果:从耐盐真菌Alternaria sp. M6的发酵液及菌丝体中分离得到9个代谢产物,分别鉴定为8-chloro-3, 6a, 7, 9, 10-pentahydroxy-9, 8, 7, 6a-tetrahydroperylen-4(6aH)-one(1),alterperylenol(2), dihydroalterperylenol(3),腺嘌呤(4),腺嘌呤核苷(5),腺嘌呤脱氧核苷(6),鸟嘌呤核苷(7),色氨酸(8),棕榈酸(9)。结论:化合物1为新的苝醌类化合物。

Abstract: AIM: To study the metabolites of a halotolerant fungus Alternaria sp. M6. METHODS: The metabolites were isolated and purified by various chromatographic techniques. Their structures were determined on the basis of physical properties and spectroscopic data. RESULTS: Nine compounds were isolated and identified as 8-chloro-3, 6a, 7, 9, 10-pentahydroxy-9, 8, 7, 6a-tetrahydroperylen-4(6aH)-one (1), alterperylenol (2), dihydroalterperylenol (3), adenine (4), adenosine (5), deoxyadenosine (6), guanosine (7), tryptophan (8), and hexadecanoic acid (9). CONCLUSION: Compound 1 is a new perylenequinone.