中国狗牙花中一个新单萜吲哚生物碱

A new monoterpenoid indole alkaloid from Ervatamia chinensis

摘要: 目的:研究中国狗牙花的化学成分。方法:采用硅胶、Sephadex LH-20、Rp-18等多种层析柱分离手段,运用NMR和HR-ESI-MS等波谱技术鉴定化合物的结构。结果:从中国狗牙花全株中分离鉴定了6个生物碱:ervachinine E (1),rutaecarpine (2), 1-methyl-2-nonyl-4(1H)-quinolone (3), dihydroevocarpine (4), evocarpine (5), 1-methyl-2-(Z)-6-undecenyl-4(1H)-quinolone (6)。结论:化合物1为新的单萜吲哚生物碱,显示中等强度的抗肿瘤活性;化合物2-6为首次从该植物中分离得到。

Abstract: AIM: To study the chemical constituents of the whole plants of E. chinensis, and find new or effective components. METHODS: Compounds were isolated by repeated silica gel and Sephadex LH-20 column chromatography. The structures were elucidated by NMR and HRESI-MS spectrometry. RESULTS: Six alkaloids were isolated from whole plants of E. chinensis, and their structures were elucidated as ervachinine E (1), rutaecarpine (2), 1-methyl-2-nonyl-4(1H)-quinolone (3), dihydroevocarpine (4), evocarpine (5), and 1-methyl-2-(Z)-6-undecenyl-4(1H)-quinolone (6), respectively. CONCLUSION: Compound 1 is a new monoterpenoid indole alkaloid and with moderate anti-tumor activity, while compounds 2-6 are reported from this species for the first time.