Abstract:
Two new neolignans and one new lignan (
1 –
3 ) were obtained from the roots of
Paeonia lactiflora. Their structures were unambiguously elucidated based on extensive spectroscopic analysis, single-crystal X-ray crystallography, and the calculated and experimental electronic circular dichroism (ECD) spectra. Compound
1 was a racemic mixture and successfully resolved into the anticipated enantiomers through chiral-phase HPLC. Compound
3 demonstrated moderate inhibitory activity against human carboxylesterase 2A1 (hCES2A1) with an IC
50 value of 7.28 ± 0.94
μmol·L
−1.
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