Abstract: Sarglanoids A–F, six new sesquiterpenoids belonging to eudesmane ( 1 – 5 ) and eremophilane ( 6 ) types, were isolated from the leaves of Sarcandra glabra, a famous traditional Chinese medicine (TCM). Their structures including absolute configurations were elucidated through extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. Compounds 1 – 2 were rare N-containing eudesmane-type sesquiterpenoids. Compound 3 exhibited inhibitory activity against nitric oxide (NO) production in lipopolysaccharides (LPS)-induced RAW 264.7 cells with an IC₅₀ value of 20.00 ± 1.30 μmol·L⁻¹. These findings provide scientific evidence for sesquiterpenoids as the material foundation of S. glabra.