Effect and mechanism of Qishen Yiqi Pills on adriamycininduced cardiomyopathy in mice

AIM:To study the effect and probable mechanism of Qishen Yiqi Pills on adriamycin(ADR)-induced cardiomyopathy in mice.METHODS:Sixty-four mice were randomly divided into(1) the ADR group:saline(1 mL/100 g) administered every day by intragavage,ADR(4 mg·kg-1) administered to each mouse by intraperitoneal injection twice a week for four weeks;(2) the ADR+Qishen Yiqi Pills I group:ADR(4 mg·kg-1) administered to each mouse by intraperitoneal injection twice a week for four weeks,and at the beginning of the third week Qishen Yiqi Pills(3.5 mg/100 g) administered by intragavage every day for four weeks;(3) the ADR+Qishen Yiqi Pills II group:ADR(4 mg·kg-1) administered to each mouse by intraperitoneal injection twice a week for four weeks,and at the same time Qishen Yiqi Pills(3.5 mg/100 g) administered by intragavage every day for four weeks;(4) the control group:saline(1 mL/100 g) administered every day by intragavage,saline(1 mL·kg-1) administered to each mouse by intraperitoneal injection twice a week for four weeks.Six weeks later,cardiac function,myocardial pathology,and expression of Bcl-2 and Bax were evaluated.RESULTS:1.The left ventricular diastolic diameter and the left ventricular systolic diameter were significantly increased(PPPCONCLUSIONS:Qishen Yiqi Pills can effectively improve the cardiac function of ADR-induced cardiomyopathy,and the earlier it is used is better.The probable mechanism of action may be the inhibition of the apoptosis of myocardial cells.