摘要: Cranberry extract (CBE) rich in polyphenols are potent to delay paralysis induced by alleviating -amyloid (A) toxicity in C. elegans model of Alzheimer's disease (AD). In order to better apply CBE as an anti-AD agent efficiently, we sought to deterrmine whether preventive or therapeutic effect contributes more prominently toward CBE's anti-AD activity. As the level of A toxicity and memory health are two major pathological parameters in AD, in the present study, we compared the effects of CBE on A toxicity and memory health in the C. elegans AD model treated with preventive and therapeutic protocols. Our results revealed that CBE prominently showed the preventive efficacy, providing a basis for further investigation of these effects in mammals.