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藏药脉花党参的化学成分

Chemical constituents from the aerial parts of Codonopsis nervosa

  • 摘要: 目的:研究藏药脉花党参Codonopsis nervosa (Chipp.) Nannf.地上部分的化学成分。方法:采用D101大孔树脂柱、硅胶柱、ODS柱、凝胶柱等色谱手段进行化学分离和纯化,并利用各种波谱技术进行结构鉴定。结果:分离并鉴定了15个化合物,分别为柯伊利素(1),苜蓿素(2),芹菜素(3),琥珀酸(4), -胡萝卜苷(5),木犀草素(6),木犀草素-7-O--D-葡萄糖苷(7),ethylsyringin (8),芹菜素-7-O--D-葡萄糖苷(9),木犀草素-7-O--D-葡萄糖基-(16)-(6'''-O-咖啡酸)--D-葡萄糖苷(10),木犀草素-7-O--D-龙胆二糖苷(11),丁香苷(12),绿原酸(13),新绿原酸(14),对羟基苯甲酸葡萄糖苷(15)。结论:化合物1-5, 8, 9, 12, 14,15均首次从该植物中分离得到。

     

    Abstract: AIM: To study the chemical constituents of the aerial parts of Codonopsis nervosa (Chipp.) Nannf. (Campanulaceae), a commonly used Tibetan herb. METHODS: The constituents were isolated by D-101 porous polymer resin, silica gel, ODS and Sephadex LH-20 column chromatography, and their structures were elucidated on the basis of spectroscopic analysis. RESULTS: 15 compounds were isolated and identified as chrysoeriol (1), tricin (2), apigenin (3), succinic acid (4), -sitosterol-3-O--D-glucopyranoside (5), luteolin (6), luteolin-7-O--D-glucopyranoside (7), ethylsyringin (8), apigenin-7-O--D-glucopyranoside (9), luteolin- 7-O--D-glucopyranosyl-(16)-6'''-O-caffeoyl--D-glucopyranoside (10), luteolin-7-O--D-gentiobioside (11), syringin (12), 3-O-caffeoylquinic acid (13), 5-O-caffeoylquinic acid (14), and 4-O-(-D-glucopyranosyl)-benzoic acid (15), respectively. CONCLUSION: Compounds 1-5, 8, 9, 12, 14, 15 were reported from C. nervosa for the first time.

     

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