Abstract:
Two new 2-carboxymethyl-3-hexyl-maleic anhydride derivatives, arthrianhydride A (
1) and B (
2) , along with three known compounds
3 −
5 , were isolated from the fermentation broth of a grasshopper-associated fungus
Arthrinium sp. NF2410. The structures of new compounds
1 and
2 were determined based on the analysis of the HR-ESI-MS and NMR spectroscopic data. Furthermore, compounds
1 and
2 were evaluated on inhibitory activity against the enzyme SHP2 and both of them showed moderate inhibitory activity against SHP2.
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