Olga QUASIE, Hui LI, Jun LUO, Ling-Yi KONG. Two new phragmalin-type limonoids orthoesters from Entandrophragma candollei[J]. Chinese Journal of Natural Medicines, 2017, 15(9): 680-683. DOI: 10.3724/SP.J.1009.2017.00680
Citation: Olga QUASIE, Hui LI, Jun LUO, Ling-Yi KONG. Two new phragmalin-type limonoids orthoesters from Entandrophragma candollei[J]. Chinese Journal of Natural Medicines, 2017, 15(9): 680-683. DOI: 10.3724/SP.J.1009.2017.00680

Two new phragmalin-type limonoids orthoesters from Entandrophragma candollei

  • Two new phragmalin-type limonoids orthoesters, encandollens A and B ( 1 and 2 ), were isolated from the stem barks of Entandrophragma candollei collected in Ghana. The structures of these compounds were elucidated on the basis of HR-ESI-MS, 1H and 13C NMR, HSQC, HMBC, and ROESY data. Compound 1 was a rare C-15 enolic acyl phragmalin-type limonoid orthoester. Compounds 1 and 2 exhibited weak inhibitory effects on NO production in lipopolysaccharide (LPS)-induced RAW 264.7 cells.
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