HU Ying, WANG Shuxian, WU Lan, YANG Kai, YANG Fan, YANG Junfa, HU Shuang, YAO Yan, XIA Xun, LIU Yixin, PENG Li, WAN Jihong, SHEN Chuanpu, XU Tao. Puerarin inhibits inflammation and lipid accumulation in alcoholic liver disease through regulating MMP8 [J].Chin J Nat Med, 2023, 21(9): 670-681. doi: 10.1016/S1875-5364(23)60399-1
Citation: HU Ying, WANG Shuxian, WU Lan, YANG Kai, YANG Fan, YANG Junfa, HU Shuang, YAO Yan, XIA Xun, LIU Yixin, PENG Li, WAN Jihong, SHEN Chuanpu, XU Tao. Puerarin inhibits inflammation and lipid accumulation in alcoholic liver disease through regulating MMP8 [J].Chin J Nat Med, 2023, 21(9): 670-681. doi: 10.1016/S1875-5364(23)60399-1

Puerarin inhibits inflammation and lipid accumulation in alcoholic liver disease through regulating MMP8

  • Alcoholic liver disease (ALD) is a growing global health concern, and its early pathogenesis includes steatosis and steatohepatitis. Inhibiting lipid accumulation and inflammation is a crucial step in relieving ALD. Evidence shows that puerarin (Pue), an isoflavone isolated from Pueraria lobata, exerts cardio-protective, neuroprotective, anti-inflammatory, antioxidant activities. However, the therapeutic potential of Pue on ALD remains unknown. In the study, both the NIAAA model and ethanol (EtOH)-induced AML-12 cell were used to explore the protective effect of Pue on alcoholic liver injury in vivo and in vitro and related mechanism. The results showed that Pue (100 mg·kg−1) attenuated EtOH-induced liver injury and inhibited the levels of SREBP-1c, TNF-α, IL-6 and IL-1β, compared with silymarin (Sil, 100 mg·kg−1). In vitro results were consistent with in vivo results. Mechanistically, Pue might suppress liver lipid accumulation and inflammation by regulating MMP8. In conclusion, Pue might be a promising clinical candidate for ALD treatment.
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