Salman Khan, ZHU Hong-Jie, SUN Zi-Qian, Li Yi-Lin, WANG Lan, WANG Rong, GUO Zhi-Kai, JIAO Rui-Hua. Isolation and Biological Activity of Seven New Drimane-Type Sesquiterpenoids from an Earwig-Associated Aspergillus sp. NF2396 [J].Chin J Nat Med, 2022, 20(0): 1-7. doi: 10.1016/S1875-5364(22)60207-3
Citation: Salman Khan, ZHU Hong-Jie, SUN Zi-Qian, Li Yi-Lin, WANG Lan, WANG Rong, GUO Zhi-Kai, JIAO Rui-Hua. Isolation and Biological Activity of Seven New Drimane-Type Sesquiterpenoids from an Earwig-Associated Aspergillus sp. NF2396 [J].Chin J Nat Med, 2022, 20(0): 1-7. doi: 10.1016/S1875-5364(22)60207-3

Isolation and Biological Activity of Seven New Drimane-Type Sesquiterpenoids from an Earwig-Associated Aspergillus sp. NF2396

  • Drimane-type sesquiterpenoids are widely distributed in fungi. From the ethyl acetate extract of the earwig-derived Aspergillus sp. NF2396, seven new drimane-type sesquiterpenoids, named drimanenoids A-G ( 1 - 7 ), were isolated. Their structures were elucidated by diverse spectroscopic analysis including high-resolution ESI-MS, one- and two-dimensional NMR spectroscopy. Drimanenoids A-F ( 1 - 6 ) are new members of drimane-type sesquiterpenoid esterified with unsaturated fatty acid side chain at C-6. The antibacterial and cytotoxic activity of these new compounds were evaluated. Compound 4 exhibited moderate cytotoxicity against human myelogenous leukemia cell line K562 with IC50 values of 12.88 ± 0.11 μM.
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