YAN Chen, LONG Qun, ZHANG Yun-Dong, BABU Gajendran, KRISHNAPRIYA Madhu Varier, QIU Jian-Fei, SONG Jing-Rui, RAO Qing, YI Ping, SUN Mao, LI Yan-Mei. Germacranolide sesquiterpenes from Carpesium cernuum and their anti-leukemia activity [J].Chin J Nat Med, 2021, 19(7): 528-535. doi: 10.1016/S1875-5364(21)60052-3
Citation: YAN Chen, LONG Qun, ZHANG Yun-Dong, BABU Gajendran, KRISHNAPRIYA Madhu Varier, QIU Jian-Fei, SONG Jing-Rui, RAO Qing, YI Ping, SUN Mao, LI Yan-Mei. Germacranolide sesquiterpenes from Carpesium cernuum and their anti-leukemia activity [J].Chin J Nat Med, 2021, 19(7): 528-535. doi: 10.1016/S1875-5364(21)60052-3

Germacranolide sesquiterpenes from Carpesium cernuum and their anti-leukemia activity

  • In this study, three new germacranolide sesquiterpenes ( 13 ), together with six related known analogues ( 49 ) were isolated from the whole plant of Carpesium cernuum. Their structures were established by a combination of extensive NMR spectroscopic analysis, HR-ESIMS data, and ECD calculations. The anti-leukemia activities of all compounds towards three cell lines (HEL, KG-1a, and K562) were evaluated in vitro. Compounds 13 exhibited moderate cytotoxicity with IC50 values ranging from 1.59 to 5.47 μmol·L−1. Mechanistic studies indicated that 2 induced apoptosis by decreasing anti-apoptotic protein Bcl-2 and activating the caspase family in K562 cells. These results suggest that compound 2 is a potential anti-leukemia agent.
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