Qiang FU, Min YANG, Yu MA, Jiang CHEN, Hai-Mei YUAN. Novel triterpene saponins isolated from Clematis mandshurica and their inhibitory activities on NO production[J]. Chinese Journal of Natural Medicines, 2018, 16(2): 131-138. DOI: 10.1016/S1875-5364(18)30039-6
Citation: Qiang FU, Min YANG, Yu MA, Jiang CHEN, Hai-Mei YUAN. Novel triterpene saponins isolated from Clematis mandshurica and their inhibitory activities on NO production[J]. Chinese Journal of Natural Medicines, 2018, 16(2): 131-138. DOI: 10.1016/S1875-5364(18)30039-6

Novel triterpene saponins isolated from Clematis mandshurica and their inhibitory activities on NO production

  • Four new triterpene saponins, mandshunosides F-I ( 1-4 ), together with five known compounds ( 5-9 ), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidences and hydrolysis products. Bisdesmosidic saponin ( 3-9 ) showed modest suppression of NO production with the inhibition ratios in the range of 51.3%-64.6% at 50 μmol·L-1, whereas monodesmosidic saponins with a free carboxyl group at C-28 ( 1 and 2 ) showed potent inhibitory activities with IC50 values being 12.7 and 8.3 μmol·L-1, respectively.
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