GUO Li-Na, ZHANG Rui, GUO Xue-Ying, CUI Tao, DONG Wei, HUO Jin-Hai, WANG Wei-Ming. Identfication of new naphthalenones from Juglans mandshurica and evalution of their anticancer activities[J]. Chinese Journal of Natural Medicines, 2015, 13(9): 707-710.
Citation: GUO Li-Na, ZHANG Rui, GUO Xue-Ying, CUI Tao, DONG Wei, HUO Jin-Hai, WANG Wei-Ming. Identfication of new naphthalenones from Juglans mandshurica and evalution of their anticancer activities[J]. Chinese Journal of Natural Medicines, 2015, 13(9): 707-710.

Identfication of new naphthalenones from Juglans mandshurica and evalution of their anticancer activities

  • Two new naphthalenone compounds were isolated from green walnut husks of Juglans mandshurica and their structures were identified as 4-butoxybutoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (1), 4-ethoxyethoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (2). Compounds 1 and 2 were named as Juglanstetralone A (1) and Juglanstetralone B (2). Compound 1 showed more significant anti-tumor activity than 2 against gastric cancer BGC-823 cells, wih the IC50 of 125.89 gmL-1.
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