YU Jun-Xian, Sukesh Voruganti, LI Dan-Dan, Jiang-Jiang Qin, Subhasree Nag, Su Xu, Sadanandan E. Velu, Wei Wang, Ruiwen ZHANG. Development and validation of an HPLC-MS/MS analytical method for quantitative analysis of TCBA-TPQ, a novel anticancer makaluvamine analog, and application in a pharmacokinetic study in rats[J]. Chinese Journal of Natural Medicines, 2015, 13(7): 554-560.
Citation: YU Jun-Xian, Sukesh Voruganti, LI Dan-Dan, Jiang-Jiang Qin, Subhasree Nag, Su Xu, Sadanandan E. Velu, Wei Wang, Ruiwen ZHANG. Development and validation of an HPLC-MS/MS analytical method for quantitative analysis of TCBA-TPQ, a novel anticancer makaluvamine analog, and application in a pharmacokinetic study in rats[J]. Chinese Journal of Natural Medicines, 2015, 13(7): 554-560.

Development and validation of an HPLC-MS/MS analytical method for quantitative analysis of TCBA-TPQ, a novel anticancer makaluvamine analog, and application in a pharmacokinetic study in rats

  • We have recently designed and synthesized several novel iminoquinone anticancer agents that have entered preclinical development for the treatment of human cancers. Herein we developed and validated a quantitative HPLC-MS/MS analytical method for one of the lead novel anticancer makaluvamine analog, TCBA-TPQ, and conducted a pharmacokinetic study in laboratory rats. Our results indicated that the HPLC-MS/MS method was precise, accurate, and specific. Using this method, we carried out in vitro and in vivo evaluations of the pharmacological properties of TCBA-TPQ and plasma pharmacokinetics in rats. Our results provide a basis for future preclinical and clinical development of this promising anticancer marine analog.
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