PENG Yu-Shuai, LIU Li-Jia, ZHAO Can, YANG Xin, LIU Chen, WANG Ru-Feng. Pharmacokinetics and tissue distributions of veratric acid after intravenous administration in rats[J]. Chinese Journal of Natural Medicines, 2015, 13(7): 535-539.
Citation: PENG Yu-Shuai, LIU Li-Jia, ZHAO Can, YANG Xin, LIU Chen, WANG Ru-Feng. Pharmacokinetics and tissue distributions of veratric acid after intravenous administration in rats[J]. Chinese Journal of Natural Medicines, 2015, 13(7): 535-539.

Pharmacokinetics and tissue distributions of veratric acid after intravenous administration in rats

  • The present study was designed to investigate the pharmacokinetics and tissue distributions of veratric acid following intravenous administration in rats. The concentrations of veratric acid in rat plasma at various times after administrated at doses of 2.5, 5, and 10 mgkg-1 were quantified by HPLC. The tissue distributions of veratric acid at various times after a single intravenous dose of 2.5 mgkg-1 were also analyzed. The plasma pharmacokinetic parameters at the three doses were as follows:t1/2, (86.236.83), (72.664.10) and (71.202.90) min; C0, (11.101.47), (23.671.24) and (39.173.90) gmL-1; and AUC0, (1 240.90129.14), (2 273.84132.47) and (3 516.4403.37) mingmL-1, respectively. The compound was distributed into tissues rapidly and extensively after intravenous administration and was mainly distributed into the liver, heart and kidneys.
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