SHAN Yan, HONG Ting, WANG Yan-Fei, ZHANG Nen-Ling, YU Bo, LU Yu, QIU Sheng-Xiang. Synthesis and cytotoxicity of longistylin C derivatives[J]. Chinese Journal of Natural Medicines, 2015, 13(4): 311-315.
Citation: SHAN Yan, HONG Ting, WANG Yan-Fei, ZHANG Nen-Ling, YU Bo, LU Yu, QIU Sheng-Xiang. Synthesis and cytotoxicity of longistylin C derivatives[J]. Chinese Journal of Natural Medicines, 2015, 13(4): 311-315.

Synthesis and cytotoxicity of longistylin C derivatives

  • The present study was designed to identify potent anti-tumor compounds from a series of new longistylin C derivatives. Ten longistylin C derivatives were synthesized and their structures were confirmed by 1H NMR, MS, and elemental analyses. Their cytotoxicity in vitro against three human cancer cell lines (A549, HepG2, and MCF-7) were evaluated by the MTT assay. Among these compounds, DT-6 and DT-9 displayed much better cytotoxicity against A549, HepG2, and MCF-7 cells, DT-1 exhibited selective cytotoxicity against HepG2, and the structure-activity relationships were investigated. In conclusion, Compounds DT-6 and DT-9 may serve as potential lead compounds for the discovery of new anti-cancer drugs.
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