XIE Wei-Jia, TANABE Genzoh, TSUTSUI Nozomi, WU Xiao-Ming, MURAOKA Osamu. Total synthesis of neokotalanol,a potent α-glucosidase inhibitor isolated from Salacia reticulata[J]. Chinese Journal of Natural Medicines, 2013, 11(6): 676-683.
Citation: XIE Wei-Jia, TANABE Genzoh, TSUTSUI Nozomi, WU Xiao-Ming, MURAOKA Osamu. Total synthesis of neokotalanol,a potent α-glucosidase inhibitor isolated from Salacia reticulata[J]. Chinese Journal of Natural Medicines, 2013, 11(6): 676-683.

Total synthesis of neokotalanol,a potent α-glucosidase inhibitor isolated from Salacia reticulata

  • Neokotalanol,a potent -glucosidase inhibitor isolated from Salacia reticulata,was synthesized through a key coupling reaction between a perbenzylated thiosugar and an appropriately protected perseitol triflate derived from D-mannose.This key step was found to be quite temperature dependent,and a simultaneous cyclization of the triflate leading to a characteristic 2,4,7-trioxabicyclo4.2.1nonane system was detected.
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