CHENG Gui-Guang, ZHAO Hai-Yun, LIU Lu, ZHAO Yun-Li, SONG Chang-Wei, GU Ji, SUN Wei-Bang, LIU Ya-Ping, LUO Xiao-Dong. Non-alkaloid constituents of Vinca major[J]. Chinese Journal of Natural Medicines, 2016, 14(1): 56-60.
Citation: CHENG Gui-Guang, ZHAO Hai-Yun, LIU Lu, ZHAO Yun-Li, SONG Chang-Wei, GU Ji, SUN Wei-Bang, LIU Ya-Ping, LUO Xiao-Dong. Non-alkaloid constituents of Vinca major[J]. Chinese Journal of Natural Medicines, 2016, 14(1): 56-60.

Non-alkaloid constituents of Vinca major

  • The present study was designed to investigate the non-alkaloid compounds from the leaves and stems of Vinca major cultivated in Yunnan Province, China. The compounds were isolated using chromatographic techniques. The structures were elucidated by 1D- and 2D-NMR spectroscopic methods in combination with UV, IR, and MS analyses. The 1, 1-diphenyl-2-picrylhydrazyl (DPPH)-scavenging activity of Compounds 1-7 were evaluated. One new iridoid glycoside (compound 1), together with 11 known compounds, were isolated from Vinca major. Compounds 1, 5, and 6 showed moderate DPPH-scavenging activity, with IC50 values being 70.6, 32.8, and 62.2 molL-1, respectively. In conclusion, compound 1 is a newly identified iridoid glycoside with moderate antioxidant activity.
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